| Tdark | Immunoglobulin lambda variable 1-44 |
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Comments
| PMID | Year | Title |
|---|---|---|
| 22158414 | 2011 | Molecular programming of B cell memory. |
| 20176268 | 2010 | Structure and function of immunoglobulins. |
| 17576170 | 2007 | Immunoglobulin somatic hypermutation. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 11955599 | 2002 | Recognition of immunoglobulins by Fcgamma receptors. |
| 11872955 | 2001 | Nomenclature of the human immunoglobulin lambda (IGL) genes. |
| 10591208 | 1999 | The DNA sequence of human chromosome 22. |
| 9712075 | 1998 | Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: human anti-N-acetylglucosamine/anti-myosin antibody V region genes. |
| 9074928 | 1997 | One-megabase sequence analysis of the human immunoglobulin lambda gene locus. |
| 8951372 | 1996 | Sequence and evolution of the human germline V lambda repertoire. |
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