Property Summary

Ligand Count 2
NCBI Gene PubMed Count 2,441
PubMed Score 24522.36
PubTator Score 11110.47

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (8)

Disease Target Count Z-score Confidence
Asthma 385 5.261 2.6
Multiple Sclerosis 540 4.957 2.5
Hypertension 396 4.515 2.3
psoriasis 6694 4.506 7.59946371389879E-5
Pleurisy 19 4.424 2.2
Mucositis 29 3.925 2.0
Brain Ischemia 110 3.512 1.8
Schizophrenia 1160 3.473 1.7
Urticaria 67 3.022 1.5
Abortion, Spontaneous 109 0.0 0.0
Adenocarcinoma 122 0.0 0.0
Alzheimer Disease 83 0.0 0.0
Anorexia 43 0.0 0.0
Anthracosis 4 0.0 0.0
Arsenic Poisoning 62 0.0 0.0
Arthritis, Experimental 39 0.0 0.0
Arthritis, Rheumatoid 174 0.0 0.0
Brain Injuries 65 0.0 0.0
Breast Neoplasms 445 0.0 0.0
Bronchopulmonary Dysplasia 3 0.0 0.0
Burns 9 0.0 0.0
Burns, Chemical 6 0.0 0.0
Calcinosis 70 0.0 0.0
Cardiomegaly 116 0.0 0.0
Cardiomyopathies 110 0.0 0.0
Chemical and Drug Induced Liver Injury 195 0.0 0.0
Cholestasis, Extrahepatic 25 0.0 0.0
Colitis 54 0.0 0.0
Colitis, Ulcerative 59 0.0 0.0
Colonic Neoplasms 142 0.0 0.0
Dermatitis, Atopic 37 0.0 0.0
Diabetes Mellitus, Experimental 108 0.0 0.0
Disease Models, Animal 155 0.0 0.0
Entamoebiasis 6 0.0 0.0
Fever 138 0.0 0.0
Fibrosis 44 0.0 0.0
Gastritis, Atrophic 4 0.0 0.0
Genetic Predisposition to Disease 27 0.0 0.0
Glomerulonephritis 46 0.0 0.0
Gout 104 0.0 0.0
HIV Wasting Syndrome 4 0.0 0.0
Heart Valve Diseases 25 0.0 0.0
Heart failure 162 0.0 0.0
Heat Stroke 13 0.0 0.0
Hemolytic-Uremic Syndrome 30 0.0 0.0
Hyperalgesia 83 0.0 0.0
Hyperemia 13 0.0 0.0
Hypersensitivity 63 0.0 0.0
Hypoglycemia 152 0.0 0.0
Hypotension 82 0.0 0.0
Infarction, Middle Cerebral Artery 33 0.0 0.0
Inflammation 120 0.0 0.0
Kearns-Sayre syndrome 7 0.0 0.0
Learning Disorders 29 0.0 0.0
Leishmaniasis, Cutaneous 8 0.0 0.0
Leishmaniasis, Visceral 13 0.0 0.0
Lethargy 77 0.0 0.0
Leukocytosis 17 0.0 0.0
Liver Cirrhosis, Experimental 769 0.0 0.0
Lung Neoplasms 232 0.0 0.0
Lymphopenia 67 0.0 0.0
MELAS syndrome 18 0.0 0.0
MERRF syndrome 6 0.0 0.0
Manganese Poisoning 11 0.0 0.0
Memory Disorders 40 0.0 0.0
Mitochondrial Myopathies 21 0.0 0.0
Muscular Diseases 27 0.0 0.0
Myocardial Infarction 151 0.0 0.0
Myocardial Ischemia 169 0.0 0.0
Necrosis 53 0.0 0.0
Neoplasm Invasiveness 161 0.0 0.0
Neoplasms 63 0.0 0.0
Neutropenia 72 0.0 0.0
Ophthalmoplegia, Chronic Progressive External 5 0.0 0.0
Optic Atrophy, Hereditary, Leber 14 0.0 0.0
Osteoarthritis 184 0.0 0.0
Osteoporosis, Postmenopausal 6 0.0 0.0
Peptic Ulcer 27 0.0 0.0
Pneumonia 174 0.0 0.0
Polymyositis 5 0.0 0.0
Pulmonary Fibrosis 106 0.0 0.0
Radiation Injuries, Experimental 11 0.0 0.0
Reperfusion Injury 86 0.0 0.0
Seizures 596 0.0 0.0
Silicosis 12 0.0 0.0
Skin Diseases 71 0.0 0.0
Sleep Wake Disorders 7 0.0 0.0
Stomach Neoplasms 300 0.0 0.0
Stomach Ulcer 18 0.0 0.0
Stroke 33 0.0 0.0
Thyroid Neoplasms 34 0.0 0.0
Trigeminal Neuralgia 24 0.0 0.0
dermatomyositis 966 0.0 0.0
glioblastoma 5792 0.0 3.70313394571113E-5
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6
Disease Target Count Z-score Confidence
Type 2 diabetes mellitus 272 0.0 0.8
Disease Target Count Z-score Confidence
Arthritis 290 7.341 3.7
periodontitis 293 6.449 3.2
Inflammatory bowel disease 151 6.368 3.2
Lung disease 142 5.968 3.0
Cancer 2499 5.912 3.0
diabetes mellitus 1728 5.752 2.9
Atherosclerosis 291 5.462 2.7
Hypersensitivity reaction type II disease 253 5.388 2.7
Brain disease 96 5.263 2.6
Cerebrovascular disease 238 5.198 2.6
Eye disease 62 5.169 2.6
Kidney disease 430 5.134 2.6
Peritonitis 43 5.092 2.5
Pancreatitis 123 4.989 2.5
Obesity 678 4.959 2.5
Synovitis 78 4.929 2.5
Dermatitis 157 4.917 2.5
Gastritis 47 4.801 2.4
Toxic encephalopathy 141 4.798 2.4
Gingivitis 29 4.74 2.4
Coronary artery disease 268 4.692 2.3
Meningitis 67 4.603 2.3
Muckle-Wells syndrome 12 4.584 2.3
Mastitis 48 4.566 2.3
Liver disease 237 4.551 2.3
Heart disease 306 4.533 2.3
Chorioamnionitis 14 4.509 2.3
Bacterial vaginosis 15 4.449 2.2
Parkinson's disease 392 4.421 2.2
Degenerative disc disease 35 4.314 2.2
Influenza 142 4.306 2.2
Vasculitis 80 4.284 2.1
Acquired immunodeficiency syndrome 197 4.246 2.1
Hyperglycemia 137 4.246 2.1
Diarrhea 253 4.23 2.1
Endometriosis 540 4.205 2.1
Dementia 175 4.059 2.0
Otitis Media 52 4.052 2.0
Allergic hypersensitivity disease 126 3.966 2.0
Endometritis 21 3.843 1.9
Salmonellosis 42 3.829 1.9
Toxic shock syndrome 28 3.736 1.9
Common cold 69 3.704 1.9
Pain agnosia 104 3.693 1.8
Neuropathy 261 3.69 1.8
Prostatitis 18 3.662 1.8
Leukopenia 72 3.652 1.8
Malaria 160 3.633 1.8
Mevalonic aciduria 16 3.607 1.8
Anemia 365 3.593 1.8
Osteoporosis 363 3.592 1.8
Rhinitis 55 3.563 1.8
Fatty liver disease 103 3.529 1.8
Perinatal necrotizing enterocolitis 21 3.52 1.8
Lymphadenitis 15 3.513 1.8
Cystitis 15 3.465 1.7
Arthropathy 43 3.462 1.7
Candidiasis 55 3.421 1.7
Bronchitis 43 3.377 1.7
Exanthem 37 3.369 1.7
Leishmaniasis 47 3.352 1.7
Shigellosis 21 3.32 1.7
Root resorption 22 3.309 1.7
Irritable bowel syndrome 60 3.299 1.6
Osteomyelitis 42 3.291 1.6
Parasitic helminthiasis infectious disease 15 3.248 1.6
Amyloidosis 67 3.237 1.6
sarcoidosis 370 3.226 1.6
Hyperuricemia 47 3.211 1.6
Infertility 188 3.205 1.6
Aortic aneurysm 38 3.204 1.6
Primary immunodeficiency disease 54 3.184 1.6
Collagen disease 27 3.143 1.6
Leprosy 73 3.135 1.6
Chlamydia 21 3.12 1.6
Hypereosinophilic syndrome 71 3.098 1.5
Chronic fatigue syndrome 25 3.078 1.5
Lipid metabolism disorder 114 3.077 1.5
Esophagitis 35 3.072 1.5
Schnitzler syndrome 4 3.069 1.5
Cholestasis 155 3.065 1.5
Pulpitis 5 3.032 1.5
Melioidosis 17 3.028 1.5
Leukostasis 5 3.021 1.5

Expression

  Differential Expression (24)

Disease log2 FC p
tuberculosis -4.500 5.6e-06
psoriasis 1.400 7.6e-05
cystic fibrosis 3.273 3.5e-05
Bipolar Disorder 3.295 2.0e-02
glioblastoma 1.100 3.7e-05
active ulcerative colitis 1.705 3.6e-02
adult high grade glioma 1.100 4.1e-05
aldosterone-producing adenoma -1.184 8.6e-03
Astrocytoma, Pilocytic 1.900 1.8e-05
Barrett's esophagus 1.800 1.2e-02
Breast cancer -1.700 4.8e-02
cutaneous lupus erythematosus 1.700 7.0e-03
ependymoma 1.100 1.5e-04
gastric cancer 1.100 4.1e-02
head and neck cancer 1.400 4.8e-04
hepatocellular carcinoma 1.200 3.1e-02
interstitial cystitis 2.000 1.9e-02
lung adenocarcinoma -1.039 1.8e-06
lung cancer -2.700 8.4e-05
lung carcinoma -2.300 2.8e-11
malignant mesothelioma -3.600 2.0e-08
non-small cell lung cancer -1.820 3.0e-09
pancreatic cancer 1.800 4.8e-03
pancreatic carcinoma 1.800 4.8e-03
See source...

Protein-protein Interaction (2)

Gene RIF (2709)

AA Sequence

MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVA      1 - 70
MDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPY     71 - 140
ELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKK    141 - 210
MEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS               211 - 269
//

Text Mined References (2449)

PMID Year Title