Property Summary

NCBI Gene PubMed Count 2,258
Grant Count 2,153
R01 Count 1,200
Funding $162,812,553.98
PubMed Score 22444.19
PubTator Score 11110.47

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (189)

Disease Z-score Confidence
Arthritis 248 7.257 3.6
periodontitis 269 6.369 3.2
Inflammatory bowel disease 142 6.282 3.1
Lung disease 132 5.873 2.9
Cancer 2,346 5.866 2.9
diabetes mellitus 1,663 5.635 2.8
Atherosclerosis 275 5.348 2.7
Hypersensitivity reaction type II diseas... 235  5.276 2.6
Alzheimer's disease 644 5.273 2.6
Asthma 349 5.199 2.6
Brain disease 83 5.138 2.6
Cerebrovascular disease 231 5.098 2.5
Kidney disease 396 5.059 2.5
Peritonitis 37 5.029 2.5
Eye disease 55 5.024 2.5
Pancreatitis 97 4.893 2.4
Synovitis 38 4.858 2.4
Multiple Sclerosis 498 4.846 2.4
Dermatitis 107 4.834 2.4
Obesity 616 4.802 2.4
Gastritis 44 4.723 2.4
Toxic encephalopathy 131 4.677 2.3
Gingivitis 19 4.637 2.3
Meningitis 46 4.6 2.3
Coronary artery disease 240 4.546 2.3
Muckle-Wells syndrome 11 4.53 2.3
tuberculosis 1,557 4.527 2.3
Chorioamnionitis 15 4.501 2.3
Mastitis 48 4.462 2.2
Liver disease 219 4.444 2.2
psoriasis 6,685 4.439 2.2
Heart disease 279 4.423 2.2
Bacterial vaginosis 15 4.418 2.2
Hypertension 287 4.404 2.2
Pleurisy 18 4.338 2.2
Parkinson's disease 364 4.26 2.1
Vasculitis 64 4.237 2.1
Acquired immunodeficiency syndrome 164 4.233 2.1
Influenza 142 4.223 2.1
Endometriosis 535 4.155 2.1
Hyperglycemia 120 4.132 2.1
Diarrhea 155 4.091 2.0
Degenerative disc disease 28 4.083 2.0
Otitis media 32 4.033 2.0
Dementia 129 3.982 2.0
cystic fibrosis 1,665 3.957 2.0
Metabolic syndrome X 155 3.876 1.9
Allergic hypersensitivity disease 123 3.835 1.9
Toxic shock syndrome 28 3.793 1.9
Endometritis 21 3.783 1.9
Common cold 63 3.67 1.8
Peptic ulcer disease 11 3.645 1.8
Leukopenia 42 3.621 1.8
Malaria 140 3.598 1.8
Mevalonic aciduria 12 3.588 1.8
Osteoporosis 257 3.585 1.8
Prostatitis 15 3.547 1.8
Anemia 252 3.544 1.8
Pain agnosia 99 3.537 1.8
Rhinitis 46 3.536 1.8
Perinatal necrotizing enterocolitis 18 3.462 1.7
Neuropathy 210 3.457 1.7
Myopathy 128 3.451 1.7
Cystitis 16 3.437 1.7
Brain Ischemia 87 3.433 1.7
Lymphadenitis 12 3.423 1.7
Shigellosis 16 3.375 1.7
Major Depressive Disorder 106 3.364 1.7
Arthropathy 34 3.357 1.7
Exanthem 39 3.343 1.7
Schizophrenia 501 3.337 1.7
Bronchitis 44 3.307 1.7
Amyloidosis 68 3.241 1.6
Fatty liver disease 84 3.232 1.6
Candidiasis 48 3.222 1.6
Parasitic helminthiasis infectious disea... 13  3.213 1.6
sarcoidosis 358 3.206 1.6
Irritable bowel syndrome 59 3.184 1.6
Infertility 163 3.168 1.6
Leishmaniasis 49 3.143 1.6
Root resorption 21 3.123 1.6
Collagen disease 25 3.102 1.6
Esophagitis 26 3.076 1.5
Chlamydia 18 3.041 1.5
Osteomyelitis 20 3.039 1.5
Leukostasis 5 3.023 1.5
Aortic aneurysm 34 3.021 1.5
Eosinophilia 65 3.016 1.5
Gingival recession 14 3.013 1.5
Tularemia 22 3.008 1.5
Adenocarcinoma 115
Anorexia 15
Anthracosis 4
Arsenic Poisoning 59
Arthritis, Experimental 39
Articular gout 11
Barrett's esophagus 183
Bipolar Disorder 266
Breast cancer 3,094
Bronchopulmonary Dysplasia 5
Calcinosis 62
Cardiomegaly 66
Cardiomyopathies 90
Cerebrovascular accident 44
Chronic progressive external ophthalmopl... 18 
Colitis 46
Colonic Neoplasms 126
Cryopyrin associated periodic syndrome 5
Deficiency of mevalonate kinase 2
Degenerative polyarthritis 93
Dermatitis, Atopic 45
Dermatologic disorders 65
Diabetes Mellitus, Experimental 106
Drug-Induced Liver Injury 118
Entamoebiasis 6
Familial Mediterranean fever 12
Fever 34
Fibrosis 40
Gastric ulcer 34
Gastritis, Atrophic 1
Glomerulonephritis 36
Gout 93
HIV Wasting Syndrome 4
Heart failure 80
Heart valve disease 24
Heat Stroke 12
Hyperalgesia 71
Hyperemia 13
Hypersensitivity 63
Hypoglycemia 81
Hypotension 53
Inflammation 109
Inflammatory disease of mucous membrane 8
Kearns-Sayre syndrome 6
Learning Disorders 27
Leishmaniasis, Cutaneous 8
Leishmaniasis, Visceral 13
Lethargy 4
Leukocytosis 2
Liver Cirrhosis, Experimental 108
Lung Neoplasms 171
Lymphopenia 35
MELAS syndrome 17
MERRF syndrome 5
Mammary Neoplasms 410
Manganese Poisoning 11
Memory Disorders 36
Mitochondrial Myopathies 6
Myocardial Infarction 126
Myocardial Ischemia 169
Necrosis 51
Neutropenia 78
Optic Atrophy, Hereditary, Leber 14
Osteoporosis, Postmenopausal 7
Peptic ulcer 22
Pneumonia 133
Polymyositis 5
Pulmonary Fibrosis 66
Reperfusion Injury 84
Rheumatoid Arthritis 1,160
Seizures 95
Silicosis 10
Sleep Wake Disorders 5
Spontaneous abortion 108
Stomach Neoplasms 282
Systemic onset juvenile chronic arthriti... 1 
TNF receptor-associated periodic fever s... 2 
Thyroid Neoplasm 33
Urticaria 53
aldosterone-producing adenoma 664
cutaneous lupus erythematosus 1,056
dermatomyositis 933
gastric cancer 430
glioblastoma 5,572
head and neck cancer 270
hemolytic-uremic syndrome 28
hepatocellular carcinoma 532
interstitial cystitis 2,299
lung adenocarcinoma 2,713
lung cancer 4,466
lung carcinoma 2,844
malignant mesothelioma 3,162
non-small cell lung cancer 2,798
pancreatic cancer 2,300
pancreatic carcinoma 567
pediatric high grade glioma 2,712
pilocytic astrocytoma 3,086
posterior fossa group A ependymoma 1,511
ulcerative colitis 2,087

Expression

  Differential Expression (24)

Disease log2 FC p
ulcerative colitis 4.200 0.000
glioblastoma 1.300 0.036
psoriasis 3.000 0.000
gastric cancer 1.100 0.041
hepatocellular carcinoma 1.200 0.031
pancreatic cancer 2.000 0.005
malignant mesothelioma -4.000 0.000
Barrett's esophagus 1.900 0.015
cutaneous lupus erythematosus 2.400 0.000
posterior fossa group A ependymoma 1.500 0.000
cystic fibrosis 3.273 0.000
tuberculosis -4.500 0.000
non-small cell lung cancer -1.820 0.000
lung cancer -4.000 0.000
Breast cancer -1.700 0.048
interstitial cystitis 2.400 0.017
pediatric high grade glioma 1.300 0.000
pilocytic astrocytoma 2.100 0.000
pancreatic carcinoma 2.000 0.005
aldosterone-producing adenoma -1.184 0.009
lung adenocarcinoma -1.039 0.000
lung carcinoma -2.300 0.000
Bipolar Disorder 3.295 0.020
head and neck cancer 1.400 0.000
See source...

Synonym

Accession P01584 Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6 IL-1 beta
Symbols IL-1
IL1F2
IL1-BETA

Gene