Tchem IL1A Interleukin-1 alpha

Protein Summary

Description

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01583
• Q53QF9
• Q7RU02
• IL-1 alpha

Gene Name

• IL1A

Ensembl ID

• ENST00000263339
• ENSP00000263339
• ENSG00000115008

Symbol

• IL1F1
• IL1
• IL-1A
• IL1F1
• IL1-ALPHA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
gene perturbation	1
biological process	0.98
virus perturbation	0.9
protein domain	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5455.07   (req: < 5)

Gene RIFs: 558   (req: <= 3)

Antibodies: 1335   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5455.07   (req: >= 5)

Gene RIFs: 558   (req: > 3)

Antibodies: 1335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1