| Tbio | Interferon gamma |
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| nasopharyngeal carcinoma | 1056 | 0.00224792644352051 |
| tuberculosis and treatment for 3 months | 327 | 0.00240459482589331 |
| interstitial cystitis | 2299 | 0.00336765451756211 |
| hepatocellular carcinoma | 550 | 0.00763299927746864 |
| Common variable immunodeficiency | 98 | 0.0128276204627582 |
| cutaneous lupus erythematosus | 1056 | 0.0189220344077281 |
| pancreatic cancer | 2300 | 0.0196775365479243 |
| pancreatic carcinoma | 567 | 0.0196775365479245 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Crohn's disease | 304 | 0.0 | 2.0 |
| ulcerative colitis | 2087 | 0.0 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| hepatocellular carcinoma | -1.600 | 0.008 |
| pancreatic cancer | -2.200 | 0.020 |
| cutaneous lupus erythematosus | 1.800 | 0.019 |
| tuberculosis and treatment for 3 months | -1.600 | 0.002 |
| Common variable immunodeficiency | 1.526 | 0.013 |
| interstitial cystitis | 2.000 | 0.003 |
| pancreatic carcinoma | -2.200 | 0.020 |
| nasopharyngeal carcinoma | 1.100 | 0.002 |
| psoriasis | 3.800 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG Inparanoid |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 27534050 | Maximum risk for Pulmonary tuberculosis is associated with a combination of the AA genotypes of the polymorphic site +874A/Tof the IFNG gene and TT polymorphism G509T of the TGFB gene (AA/TT). |
| 27455566 | Interferon-gamma polymorphisms determine human brucellosis predisposition and severity. (Review) |
| 27053161 | this study highlights the molecular basis for posttranslational modifications of Gata3 that control the regulation of IFNgamma expression in memory Th2 cells. |
| 27015189 | This study suggests IFN-gamma +874T/A polymorphism are related to CML and CLL risk. In addition, our work also points out IFN-gamma +874T/A polymorphism may play dual contrasting role in leukemia risk. |
| 26927386 | Data show that during chronic HBV infection, interferon gamma (IFN-gamma) and interleukin 4 (IL-4 )expressed by peripheral blood T cells play dual immunoregulatory roles, which are correlated with the efficacy of entecavir. |
| 26904697 | The increased production of TNF-alpha and IFN-gamma in of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1 infection. |
| 26893439 | IFN-gamma rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of hepatocellular carcinoma. |
| 26881918 | Our results suggested that TNF-alpha may be an ideal biomarker for diagnosing the 3 forms of TB presentation, while the other factors (IL-6, IP-10, MCP-1, and IFN-gamma) can potentially facilitate differential diagnosis for the 3 TB presentation types |
| 26881863 | Low interferon-gamma relative-response to cytomegalovirus is associated with low likelihood of intrauterine transmission of the virus. |
| 26783516 | Baicalin exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-g in major IFN-g producing cells. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 27534050 | 2010 | [ALLELE POLYMORPHISM OF THE IFNG AND TGFB GENES AS A FACTOR OF MODULATION OF CYTOKINE SECRETION AND SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS]. |
| 27455566 | 2016 | [THE PERSPECTIVES OF STUDYING OF POLYMORPHISM OF GENES OF GAMMA-INTERFERON UNDER CHRONIC BRUCELLOSIS]. |
| 27053161 | 2016 | Akt1-mediated Gata3 phosphorylation controls the repression of IFN? in memory-type Th2 cells. |
| 27015189 | 2016 | Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis. |
| 26927386 | 2016 | [Alterations of IFN-? and IL-4 of peripheral blood T cells in patients with chronic HBV infection]. |
| 26904697 | 2016 | Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. |
| 26893439 | 2016 | Interaction Between Polymorphisms of IFN-? and MICA Correlated with Hepatocellular Carcinoma. |
| 26881918 | 2016 | Analysis of Plasma Cytokine and Chemokine Profiles in Patients with and without Tuberculosis by Liquid Array-Based Multiplexed Immunoassays. |
| 26881863 | 2016 | Low Interferon Relative-Response to Cytomegalovirus Is Associated with Low Likelihood of Intrauterine Transmission of the Virus. |
| 26783516 | 2015 | Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma. |
| More... |
