| Tbio | Interferon gamma |
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Comments
Property Summary
| NCBI Gene PubMed Count | 1,538 |
| Grant Count | 2,768 |
| R01 Count | 1,413 |
| Funding | $352,443,509.28 |
| PubMed Score | 5432.39 |
| PubTator Score | 15643.20 |
| Disease | log2 FC | p |
|---|---|---|
| hepatocellular carcinoma | -1.600 | 0.008 |
| pancreatic cancer | -2.200 | 0.020 |
| cutaneous lupus erythematosus | 1.800 | 0.019 |
| tuberculosis and treatment for 3 months | -1.600 | 0.002 |
| Common variable immunodeficiency | 1.526 | 0.013 |
| interstitial cystitis | 2.000 | 0.003 |
| pancreatic carcinoma | -2.200 | 0.020 |
| nasopharyngeal carcinoma | 1.100 | 0.002 |
| psoriasis | 3.800 | 0.000 |