Tbio OXT Oxytocin-neurophysin 1

Protein Summary

Description

Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156). This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• P01178
• Q3MIG0
• OT-NPI

Gene Name

• OXT

Ensembl ID

• ENST00000217386
• ENSP00000217386
• ENSG00000101405

Symbol

• OT
• OT
• OT-NPI
• OXT-NPI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
biological term	0.89
gene perturbation	0.72
disease	0.7
phenotype	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Neuropeptide / Oxytocin-neurophysin 1

DTO Classes

Protein / Signaling / Hormone / Neuropeptide / Oxytocin-neurophysin 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22640.63   (req: < 5)

Gene RIFs: 164   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22640.63   (req: >= 5)

Gene RIFs: 164   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0