Property Summary

NCBI Gene PubMed Count 3,362
Grant Count 7,330
R01 Count 4,298
Funding $838,405,487.06
PubMed Score 20956.55
PubTator Score 14221.43

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (139)

Disease Z-score Confidence
Cancer 2,346 6.938 3.5
Kidney disease 396 6.682 3.3
Lung disease 132 6.055 3.0
Ureteral disease 23 5.741 2.9
Hypersensitivity reaction type II diseas... 235  5.524 2.8
Collagen disease 25 5.414 2.7
Liver disease 219 5.26 2.6
Asthma 349 5.225 2.6
Arthritis 248 5.21 2.6
diabetes mellitus 1,663 5.189 2.6
Hypertension 287 5.076 2.5
Hereditary hemorrhagic telangiectasia 14 4.927 2.5
Inflammatory bowel disease 142 4.916 2.5
Heart disease 279 4.735 2.4
Atherosclerosis 275 4.496 2.2
Camurati-Engelmann disease 5 4.45 2.2
Loeys-Dietz syndrome 23 4.379 2.2
Multiple Sclerosis 498 4.331 2.2
Allergic hypersensitivity disease 123 4.294 2.1
Coronary artery disease 240 4.273 2.1
Peyronie's disease 8 4.259 2.1
Proliferative vitreoretinopathy 17 4.205 2.1
Leishmaniasis 49 4.134 2.1
Pancreatitis 97 4.007 2.0
Glaucoma 134 3.998 2.0
Osteoporosis 257 3.932 2.0
Hyperglycemia 120 3.93 2.0
Periodontal disease 37 3.921 2.0
tuberculosis 1,557 3.905 2.0
Cleft palate 125 3.706 1.9
Obesity 616 3.654 1.8
Dermatitis 107 3.639 1.8
Aortic aneurysm 34 3.631 1.8
Cerebrovascular disease 231 3.573 1.8
Hepatitis C 90 3.538 1.8
Myopathy 128 3.53 1.8
Oral Submucous Fibrosis 18 3.501 1.8
Cholestasis 93 3.454 1.7
Chronic fatigue syndrome 29 3.443 1.7
Peripheral vascular disease 90 3.385 1.7
Adenoma 165 3.358 1.7
Schistosomiasis 38 3.349 1.7
Diabetic Retinopathy 53 3.348 1.7
Allergic rhinitis 91 3.338 1.7
Human immunodeficiency virus infectious ... 92  3.333 1.7
Eosinophilia 65 3.328 1.7
Endometriosis 535 3.301 1.7
Hepatitis B 103 3.217 1.6
Portal hypertension 21 3.18 1.6
Common cold 63 3.176 1.6
Malaria 140 3.149 1.6
Retinal detachment 33 3.107 1.6
Marfan Syndrome 14 3.101 1.6
Neuropathy 210 3.095 1.5
Alzheimer's disease 644 3.089 1.5
Peritonitis 37 3.03 1.5
Corneal disease 32 3.024 1.5
Acromicric Dysplasia 4
Acute Lung Injury 18
Acute kidney injury 65
Adenocarcinoma 115
Aortic valve insufficiency 22
Berylliosis 16
Camurati-Engelmann Syndrome 1
Carcinosarcoma 6
Cerebrovascular accident 44
Chronic Obstructive Airway Disease 47
Colorectal Cancer 47
Colorectal Neoplasms 217
Copper-Overload Cirrhosis 11
Diabetes Mellitus, Experimental 106
Diabetes Mellitus, Non-Insulin-Dependent 157
Diabetic Nephropathy 37
Diabetic Neuropathies 13
Diaphragmatic Hernia 40
Dry Eye Syndromes 2
Duodenal ulcer 20
Endomyocardial Fibrosis 10
Fibrosis 40
Focal glomerulosclerosis 22
Hepatitis, Autoimmune 17
Hepatitis, Chronic 22
Hyperplasia 26
Hypersensitivity 63
Hypertensive disease 193
IGA Glomerulonephritis 454
Inflammation 109
Intervertebral Disc Degeneration 5
Kidney Diseases 86
Kidney Failure, Chronic 45
Liver Cirrhosis 101
Liver Cirrhosis, Alcoholic 16
Liver Cirrhosis, Experimental 108
Liver carcinoma 217
Lung Neoplasms 171
Lung diseases 48
Migraine Disorders 26
Muscular Dystrophy, Duchenne 7
Myocardial Infarction 126
Neoplasm Invasiveness 127
Neoplasm Metastasis 138
Neoplastic Cell Transformation 81
Nephrotic Syndrome 48
Non-alcoholic Fatty Liver Disease 40
Osteoporosis, Postmenopausal 7
Pancreatic Neoplasm 79
Papilloma 27
Peritoneal Fibrosis 1
Peyronie Disease 1
Pneumonia 133
Prostatic Neoplasms 471
Proteinuria 63
Pulmonary Fibrosis 66
Pulmonary emphysema 34
Sepsis 21
Skin Neoplasms 49
Spontaneous abortion 108
Squamous cell carcinoma 94
Thrombocythemia, Essential 12
Uremia 19
Ureteral obstruction 6
Urticaria 53
Ventricular Remodeling 5
astrocytic glioma 2,241
atypical teratoid / rhabdoid tumor 4,369
cystic fibrosis 1,665
ependymoma 2,514
gastric carcinoma 832
glioblastoma 5,572
lung carcinoma 2,844
malignant mesothelioma 3,162
medulloblastoma 1,524
osteosarcoma 7,933
pancreatic cancer 2,300
pediatric high grade glioma 2,712
pilocytic astrocytoma 3,086
primary pancreatic ductal adenocarcinoma 1,271
sarcoidosis 358
ulcerative colitis 2,087

Expression

  Differential Expression (15)

Disease log2 FC p
malignant mesothelioma 1.100 0.000
astrocytic glioma 1.700 0.004
ependymoma 1.400 0.026
glioblastoma 2.800 0.000
osteosarcoma 1.297 0.019
atypical teratoid / rhabdoid tumor 1.200 0.002
medulloblastoma 1.300 0.016
primary pancreatic ductal adenocarcinoma 1.560 0.004
diabetes mellitus -1.700 0.006
pediatric high grade glioma 2.100 0.000
pilocytic astrocytoma 2.000 0.000
lung carcinoma -1.700 0.000
gastric carcinoma 1.600 0.006
ulcerative colitis 1.800 0.001
pancreatic cancer 1.500 0.003
See source...

Synonym

Accession P01137 A8K792 Q9UCG4 TGF-beta-1
Symbols CED
LAP
DPD1
TGFB
TGFbeta

Gene

PANTHER Protein Class (2)