Tbio PDGFB Platelet-derived growth factor subunit B

Protein Summary

Description

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P01127
• G3XAG8
• P78431
• Q15354
• Q6FHE7
• Q9UF23
• PDGF subunit B

Gene Name

• PDGFB

Ensembl ID

• ENST00000331163
• ENSP00000330382
• ENSG00000100311
• ENST00000381551
• ENSP00000370963

Symbol

• PDGF2
• SIS
• SIS
• SSV
• IBGC5
• PDGF2
• c-sis
• PDGF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.98
chemical	0.92
PubMedID	0.92
cell type or tissue	0.79

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Platelet-derived Growth Factor Subunit B

DTO Classes

Protein / Signaling / Growth Factor / Platelet-derived Growth Factor Subunit B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2043.63   (req: < 5)

Gene RIFs: 256   (req: <= 3)

Antibodies: 605   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2043.63   (req: >= 5)

Gene RIFs: 256   (req: > 3)

Antibodies: 605   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 73

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0