Protein Summary
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated ...more
- ENST00000311189
- ENSP00000309845
- ENSG00000174775
- ENST00000397594
- ENSP00000380722
- ENST00000397596
- ENSP00000380723
- ENST00000417302
- ENSP00000388246
- ENST00000451590
- ENSP00000407586
- ENST00000493230
- ENSP00000434023
- ENST00000610977
- ENSP00000480686
- ENSG00000276536
- ENST00000615062
- ENSP00000482366
- ENST00000616241
- ENSP00000480317
- ENST00000631404
- ENSP00000488757
- ENST00000631967
- ENSP00000488225
- ENST00000634098
- ENSP00000488296
- HRAS1
- CTLO
- KRAS
- HAMSV
- HRAS1
- KRAS2
- RASH1
- RASK2
- Ki-Ras
- p21ras
- C-H-RAS
- c-K-ras
- H-RASIDX
- c-Ki-ras
- C-BAS/HAS
- C-HA-RAS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
pathway | 1 | ||
chemical | 0.99 | ||
hub protein | 0.99 | ||
phenotype | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14555.67 (req: < 5)
Gene RIFs: 513 (req: <= 3)
Antibodies: 683 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14555.67 (req: >= 5)
Gene RIFs: 513 (req: > 3)
Antibodies: 683 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 49
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2