Tbio ASS1 Argininosuccinate synthase

Protein Summary

Description

One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of this gene cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P00966
• Q6LDL2
• Q86UZ0
• Q96GT4

Gene Name

• ASS1

Ensembl ID

• ENST00000352480
• ENSP00000253004
• ENSG00000130707
• ENST00000372393
• ENSP00000361469
• ENST00000372394
• ENSP00000361471

Symbol

• ASS
• ASS
• CTLN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
biological process	0.97
transcription factor perturbation	0.97
molecular function	0.96
PubMedID	0.93

Protein Classes

PANTHER Classes

Protein / Ligase / Argininosuccinate Synthase

DTO Classes

Protein / Enzyme / Ligase / Argininosuccinate Synthase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.33   (req: < 5)

Gene RIFs: 76   (req: <= 3)

Antibodies: 416   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.33   (req: >= 5)

Gene RIFs: 76   (req: > 3)

Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0