Tclin CA1 Carbonic anhydrase 1

Protein Summary

Description

Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• P00915

Gene Name

• CA1

Ensembl ID

• ENST00000431316
• ENSP00000392338
• ENSG00000133742
• ENST00000523022
• ENSP00000429798
• ENST00000523953
• ENSP00000430656
• ENST00000542576
• ENSP00000443517

Symbol

• CAB
• CA-I
• Car1
• HEL-S-11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	0.89
cell type or tissue	0.76
chemical	0.69
molecular function	0.6
gene perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2054.04   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 583   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2054.04   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 583   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4084

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20