Property Summary

NCBI Gene PubMed Count 198
PubMed Score 678.11
PubTator Score 2805.47

Knowledge Summary


No data available


  Disease Sources (8)

Disease Target Count
Hairy Cell Leukemia 6
Disease Target Count P-value
ulcerative colitis 2087 3.88388056275263E-5
cystic fibrosis 1670 6.60388058544095E-5
medulloblastoma, large-cell 6234 7.50125068527581E-5
tuberculosis and treatment for 3 months 327 2.03294834521616E-4
interstitial cystitis 2299 2.54307021873854E-4
ovarian cancer 8492 3.99581604938603E-4
group 4 medulloblastoma 1875 5.40453487305041E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00181198037140202
nasopharyngeal carcinoma 1056 0.0038140164224499
inflammatory breast cancer 404 0.0103204771284332
gastric carcinoma 832 0.0111397115962027
ependymoma 2514 0.0277786571849091
active Crohn's disease 918 0.0480095576649759
Disease Target Count Z-score Confidence
Adenosine deaminase deficiency 3 0.0 5.0


  Differential Expression (13)


Accession P00813 Q53F92 Q6LA59



PANTHER Protein Class (2)


1M7M   3IAR  

  Ortholog (16)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid
C. elegans EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (158)

26707067 We conclude that pleural ADA activity could be integrated in the diagnostic procedures of pTB in low to medium tuberculosis prevalence settings.
26376800 variable mutations are identified as a cause of immunodeficiency in a single Italian center
26329539 ADA and ADK are involved in glioma progression; increased ADA and ADK levels in peritumoral tissues may be associated with epilepsy in glioma patients.
26310829 In autologous cocultures of T cells with HIV-1-pulsed dendritic cells, adenosine deaminase decreased HIV-1-induced CD4(+)CD25(hi) FOXP3(+) cells and enhanced the HIV-1-specific CD4(+) responder T cells.
26261621 Pleural ADA activity is an accurate test for the diagnosis of tuberculous pleural effusions.
26216523 ADA6, PTPN22 and ACP1 are involved in immune reactions: since endometriosis has an autoimmune component.
26166670 activity of ADA isoenzymes and distribution of ADA1 G22 A genotypes were different among fertile and infertile men and more likely the GA genotype, which had lower ADA1 activity and was higher in fertile men is a protective factor against infertility.
25963491 Multiplex PCR and thoracoscopy are useful investigations in the diagnostic work-up of pleural effusions complicating CKD while the sensitivity and/or specificity of ADA and 65 kDa gene PCR is poor
25764155 Serum ADA levels were increased in secondary hemophagocytic lymphohistiocytosis suggesting a partial role of activated T-cell response in the disease pathophysiology.
25647479 the diagnostic utility of pfADA in a low mTB incidence area

AA Sequence

YGMPPSASAGQNL                                                             351 - 363

Text Mined References (206)

PMID Year Title
26707067 2016 Adenosine deaminase is a useful biomarker to diagnose pleural tuberculosis in low to medium prevalence settings.
26376800 2015 Diagnosis, Treatment and Long-Term Follow Up of Patients with ADA Deficiency: a Single-Center Experience.
26329539 2015 Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy.
26310829 2016 Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1.
26261621 2015 Combined evaluation of adenosine deaminase level and histopathological findings from pleural biopsy with Cope's needle for the diagnosis of tuberculous pleurisy.
26216523 2016 The effect of ACP1, ADA6 and PTPN22 genetic polymorphisms on the association between p53 codon 72 polymorphism and endometriosis.
26166670 2015 The Role of G22 A Adenosine Deaminase 1 Gene Polymorphism and the Activities of ADA Isoenzymes in Fertile and Infertile Men.
25963491 2015 Utility of adenosine deaminase (ADA), PCR & thoracoscopy in differentiating tuberculous & non-tuberculous pleural effusion complicating chronic kidney disease.
25764155 2015 Elevated serum adenosine deaminase levels in secondary hemophagocytic lymphohistiocytosis.
25647479 2015 Pleural fluid adenosine deaminase (pfADA) in the diagnosis of tuberculous effusions in a low incidence population.