Property Summary

NCBI Gene PubMed Count 224
PubMed Score 31987.60
PubTator Score 17376.35

Knowledge Summary


No data available


  Disease Sources (6)

Disease Target Count
Hypertensive disorder 58
Disease Target Count P-value
urothelial carcinoma 318 0.049843965375791


  Differential Expression (2)

Disease log2 FC p
psoriasis 3.700 0.000
urothelial carcinoma -2.200 0.050


Accession P00797 Q6FI38 Q6T5C2
Symbols HNFJ2



PANTHER Protein Class (3)


2X0B   1BBS   1BIL   1BIM   1HRN   1RNE   2BKS   2BKT   2FS4   2G1N   2G1O   2G1R   2G1S   2G1Y   2G20   2G21   2G22   2G24   2G26   2G27   2I4Q   2IKO   2IKU   2IL2   2REN   2V0Z   2V10   2V11   2V12   2V13   2V16   3D91   3G6Z   3G70   3G72   3GW5   3K1W   3KM4   3O9L   3OAD   3OAG   3OOT   3OQF   3OQK   3OWN   3Q3T   3Q4B   3Q5H   3SFC   3VCM   3VSW   3VSX   3VUC   3VYD   3VYE   3VYF   4AMT   4GJ5   4GJ6   4GJ7   4GJ8   4GJ9   4GJA   4GJB   4GJC   4GJD   4PYV   4Q1N   4RYC   4RYG   4RZ1   4S1G   4XX3   4XX4  

  Ortholog (10)

Species Source
Chimp OMA EggNOG Inparanoid
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG
Platypus OMA EggNOG
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (186)

26753721 The present study provides evidence that the rs1464816 polymorphism in REN is associated with CKD progression in ADPKD.
26489635 Increased plasma renin, AT and VEGF might play a role in the onset or development of superficial infantile hemangiomas.
26366736 The results suggest that variants in the enhancer region of the human renin gene have an effect on the expression levels of renin in renal tissue; this observation is in good accordance with the results of the transcriptional assay.
26163660 Active renin was not significantly different between hypertensive patients with and without left ventricular hypertrophy.
26102248 our data suggest that the renin polymorphism plays an important role in the risk of developing coronary artery disease with the highest risk for C allele, but do not support its role as a risk factor for developing restenosis after coronary stenting
26076559 This study showed no involvement of A/G renin polymorphisms in the pathogenesis of heart failure.
25849646 Salt supplementation blunts the telmisartan induced increase in plasma renin activity in patients with type 2 diabetes.
25767135 Elevated levels of circulating (pro)renin were observed in pre-eclampsia patients
25660845 We conclude that heterozygous substitutions at AGT and REN loci correlate significantly with end-stage renal disease in a north Indian population
25534858 Data show that administration of bone-marrow-derived stromal cells (BMSCs) with human transgenic angiotensinogen and renin genes in the mouse acute kidney injury (AKI) model resulted in exacerbation of kidney injury.

AA Sequence


Text Mined References (224)

PMID Year Title
26753721 2016 Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD.
26489635 2015 Effect of topical propranolol gel on plasma renin, angiotensin II and vascular endothelial growth factor in superficial infantile hemangiomas.
26366736 2015 A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression.
26163660 2016 Association of Post-Saline Load Plasma Aldosterone Levels With Left Ventricular Hypertrophy in Primary Hypertension.
26102248 2015 The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting.
26076559 Renin Genetic Polymorphism in Heart Failure Patients.
25849646 2015 Short-term dietary salt supplementation blunts telmisartan induced increases in plasma renin activity in hypertensive patients with type 2 diabetes mellitus.
25767135 2015 Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia.
25660845 2015 M235T polymorphism in the AGT gene and A/G(I8-83) substitution in the REN gene correlate with end-stage renal disease.
25534858 2015 Exacerbation of acute kidney injury by bone marrow stromal cells from rats with persistent renin-angiotensin system activation.