Tbio MOS Proto-oncogene serine/threonine-protein kinase mos

Protein Summary

Description

MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

Uniprot Accession IDs

• P00540
• Q3KPG9
• Q3KPH0

Gene Name

• MOS

Ensembl ID

• ENST00000311923
• ENSP00000310722
• ENSG00000172680

Symbol

• MSV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
biological process	0.83
cell type or tissue	0.81
gene perturbation	0.62
protein domain	0.58

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Mos Family / Proto-oncogene Serine/threonine-protein Kinase Mos

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0