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  5. Cytochrome c oxidase subunit 1

Tchem Cytochrome c oxidase subunit 1

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

 Comments

Property Summary

Ligand Count 2
NCBI Gene PubMed Count 1
PubMed Score 4610.42
PubTator Score 3501.07

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count
Abdominal Pain 98
Abnormality of mitochondrial metabolism 9
Acidosis, Lactic 97
Animal Mammary Neoplasms 136
Anorexia 43
Anxiety 136
Anxiety disease 113
Attention deficit hyperactivity disorder 278
Blepharoptosis 231
Blind spot located at fixation point 21
Blindness, Cortical 24
Blurred vision 19
Brain Ischemia 110
Cachexia 50
Cerebellar Ataxia 304
Cerebellar hypoplasia and atrophy 41
Cerebral Ischemia 37
Cerebral atrophy 178
Cerebral calcification 43
Clonus 18
Colorectal cancer 25
Congenital Bilateral Cataracts 50
Congenital cataract 50
Congestive heart failure 113
Cortical visual impairment 24
Creatine phosphokinase serum increased 110
Cytochrome-c Oxidase Deficiency 17
DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL 4
Death in early adulthood 24
Decreased nerve conduction velocity 35
Decreased visual acuity, slowly progressive 13
Dementia 175
Depressive disorder 409
Developmental regression 95
Diabetes Mellitus, Non-Insulin-Dependent 145
Disturbance of consciousness 12
Electromyogram abnormal 49
Elevated creatine kinase 110
Encephalopathies 43
Episodic vomiting 10
Fatigue 182
Forgetful 40
Frequent vomiting 10
Genetic recurrent myoglobinuria 3
Hallucinations 34
Hallucinations, Sensory 33
Hearing loss, progressive sensorineural 23
Heart failure 162
Hemianopsia 15
Hemiparesis 34
Highly variable severity 157
Hypertensive disease 292
Increase in blood pressure 119
Increased serum lactate 60
Intermittent migraine headaches 68
Lactic acidemia 95
Left Ventricular Hypertrophy 47
Loss of developmental milestones 95
Memory Loss 40
Memory impairment 40
Mental deterioration in childhood 95
Migraine Disorders 76
Mitochondrial Myopathies 21
Mitochondrial respiratory chain defects 15
Muscle Weakness 170
Myopathy 185
Nausea and vomiting 97
Neurodevelopmental regression 95
Ophthalmoplegia 106
Optic Atrophy 242
Optic Atrophy, Hereditary, Leber 14
Pancreatitis 123
Psychomotor regression 95
Psychomotor regression beginning in infancy 95
Psychomotor regression in infants 95
Psychomotor regression, progressive 95
Ragged-red fibers 21
Respiratory Insufficiency 132
Respiratory function loss 121
Retinal telangiectasia 12
Scotoma, Central 21
Scotoma, Centrocecal 11
Sensorineural Hearing Loss (disorder) 284
Sensorineural hearing loss, bilateral 18
Short stature 531
Slow decrease in visual acuity 13
Stroke-like episodes 10
Tonic - clonic seizures 44
Tortuous retinal vessels 15
Variable expressivity 157
Wolff-Parkinson-White syndrome 19
abnormal growth 26
diabetes mellitus 1728
Disease Target Count Z-score Confidence
Leber hereditary optic neuropathy 14 3.306 1.7
Nonsyndromic deafness 142 0.0 4.0

Expression

Synonym

Accession P00395 Q34770
Symbols COI
MTCO1

Gene

MT-CO1

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

 UniProt Keyword (21)

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 GO Function (3)

 GO Component (4)

 GO Process (8)

 Compartment GO Term (65)

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 MGI Phenotype (6)

 HCA RNA Cell Line (56)

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Pathway (25)

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Ligand (2)

Structure of CHEMBL1773877

CHEMBL1773877
pIC50 6.62

Structure of CHEMBL1774043

CHEMBL1774043
pIC50 6.89

Gene RIF (35)

AA Sequence 

MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMV      1 - 70
MPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPG     71 - 140
ASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLL    141 - 210
TDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSI    211 - 280
GFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTV    281 - 350
GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG    351 - 420
VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSM    421 - 490
NLEWLYGCPPPYHTFEEPVYMKS                                                   491 - 513
//

Text Mined References (20)

PMID Year Title