Tchem ALDH1A1 Retinal dehydrogenase 1

Protein Summary

Description

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233). The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• P00352
• O00768
• Q5SYR1
• RALDH 1

Gene Name

• ALDH1A1

Ensembl ID

• ENST00000297785
• ENSP00000297785
• ENSG00000165092

Symbol

• ALDC
• ALDH1
• PUMB1
• ALDC
• ALDH1
• HEL-9
• HEL12
• PUMB1
• ALDH11
• RALDH1
• ALDH-E1
• HEL-S-53e

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
transcription factor perturbation	0.94
gene perturbation	0.92
biological term	0.91
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Retinal Dehydrogenase 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Retinal Dehydrogenase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1036.62   (req: < 5)

Gene RIFs: 330   (req: <= 3)

Antibodies: 956   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1036.62   (req: >= 5)

Gene RIFs: 330   (req: > 3)

Antibodies: 956   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 200

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2