LDHA
L-lactate dehydrogenase A chain
Protein Summary
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
- ENST00000227157
- ENSP00000227157
- ENSG00000134333
- ENST00000379412
- ENSP00000368722
- ENST00000396222
- ENSP00000379524
- ENST00000422447
- ENSP00000395337
- ENST00000430553
- ENSP00000406172
- ENST00000540430
- ENSP00000445175
- ENST00000542179
- ENSP00000445331
- LDHM
- GSD11
- PIG19
- HEL-S-133P
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
protein complex | 1 | ||
virus perturbation | 0.98 | ||
kinase perturbation | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1708.24 (req: < 5)
Gene RIFs: 213 (req: <= 3)
Antibodies: 810 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1708.24 (req: >= 5)
Gene RIFs: 213 (req: > 3)
Antibodies: 810 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 287
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0