| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2849 | 4.5e-11 |
| medulloblastoma, large-cell | 6234 | 3.2e-05 |
| medulloblastoma | 1524 | 3.3e-05 |
| ulcerative colitis | 2087 | 5.3e-05 |
| lung cancer | 4473 | 8.6e-05 |
| lung adenocarcinoma | 2714 | 1.7e-04 |
| glioblastoma | 5572 | 2.5e-04 |
| atypical teratoid / rhabdoid tumor | 4369 | 5.9e-04 |
| primitive neuroectodermal tumor | 3031 | 6.3e-04 |
| psoriasis | 6685 | 8.0e-04 |
| osteosarcoma | 7933 | 1.8e-03 |
| Atopic dermatitis | 944 | 2.2e-03 |
| ovarian cancer | 8491 | 5.0e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 6.4e-03 |
| ependymoma | 2514 | 6.6e-03 |
| Parkinson's disease | 364 | 7.9e-03 |
| astrocytoma | 1493 | 2.0e-02 |
| Pick disease | 1893 | 3.1e-02 |
| adult high grade glioma | 2148 | 4.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Narcolepsy | 69 | 3.644 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | -1.300 | 2.0e-02 |
| ependymoma | -1.500 | 6.6e-03 |
| psoriasis | -1.300 | 8.0e-04 |
| glioblastoma | -1.800 | 2.5e-04 |
| oligodendroglioma | -1.200 | 4.5e-11 |
| osteosarcoma | 1.431 | 1.8e-03 |
| medulloblastoma | -1.800 | 3.3e-05 |
| atypical teratoid / rhabdoid tumor | -2.500 | 5.9e-04 |
| medulloblastoma, large-cell | -2.600 | 3.2e-05 |
| primitive neuroectodermal tumor | -1.700 | 6.3e-04 |
| Atopic dermatitis | -1.100 | 2.2e-03 |
| intraductal papillary-mucinous adenoma (... | 1.700 | 6.4e-03 |
| lung cancer | 3.700 | 8.6e-05 |
| Parkinson's disease | -2.100 | 7.9e-03 |
| adult high grade glioma | -1.200 | 4.2e-02 |
| lung adenocarcinoma | 1.149 | 1.7e-04 |
| Pick disease | -1.100 | 3.1e-02 |
| ulcerative colitis | -1.600 | 5.3e-05 |
| ovarian cancer | 1.600 | 5.0e-03 |
| PMID | Text | |
|---|---|---|
| 26616534 | OXR1 may act as a sensor of cellular oxidative stress to regulate the transcriptional networks required to detoxify reactive oxygen species and modulate cell cycle and apoptosis. | |
| 25792726 | Oxr1 serves as a potential therapeutic target for ALS and other neurodegenerative disorders characterized by TDP-43 or FUS pathology. | |
| 25236744 | OXR1 upregulates the expression of antioxidant genes via the p21 signaling pathway to suppress hydrogen peroxide-induced oxidative stress and maintain mtDNA integrity. | |
| 22873401 | The protein segment encoded by exon 8 plays an important role in the anti-oxidative function of the human OXR1 protein. | |
| 20877624 | Observational study of gene-disease association. (HuGE Navigator) | |
| 17391516 | human OXR1 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance. | |
| 15060142 | Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage. |
MTKDKNSPGLKKKSQSVDINAPGFNPLAGAGKQTPQASKPPAPKTPIIEEEQNNAANTQKHPSRRSELKR 1 - 70 FYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTVESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVL 71 - 140 YVPDPEYVSSVESSPSLSPVSPLSPTSSEAEFDKTTNPDVHPTEATPSSTFTGIRPARVVSSTSEEEEAF 141 - 210 TEKFLKINCKYITSGKGTVSGVLLVTPNNIMFDPHKNDPLVQENGCEEYGIMCPMEEVMSAAMYKEILDS 211 - 280 KIKESLPIDIDQLSGRDFCHSKKMTGSNTEEIDSRIRDAGNDSASTAPRSTEESLSEDVFTESELSPIRE 281 - 350 ELVSSDELRQDKSSGASSESVQTVNQAEVESLTVKSESTGTPGHLRSDTEHSTNEVGTLCHKTDLNNLEM 351 - 420 AIKEDQIADNFQGISGPKEDSTSIKGNSDQDSFLHENSLHQEESQKENMPCGETAEFKQKQSVNKGKQGK 421 - 490 EQNQDSQTEAEELRKLWKTHTMQQTKQQRENIQQVSQKEAKHKITSADGHIESSALLKEKQRHRLHKFLC 491 - 560 LRVGKPMRKTFVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDTGEYTREPGFIV 561 - 630 VKKIEESETIEDSSNQAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITTREDINSKQVATVKADLE 631 - 700 SESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMVIKDS 701 - 770 DGQVFGALASEPLKVSDGFYGTGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGD 771 - 840 LYHGRSHSCKTFGNRTLSKKEDFFIQDIEIWAFE 841 - 874 //
| PMID | Year | Title | |
|---|---|---|---|
| 26616534 | 2015 | Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway. | |
| 25792726 | 2015 | Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations. | |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 25236744 | 2014 | Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. | |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 22873401 | 2012 | Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function. | |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. | |
| 21269460 | 2011 | Initial characterization of the human central proteome. | |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. | |
| 19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. | |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. | |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. | |
| 17516841 | 2007 | Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. | |
| 17391516 | 2007 | The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins. | |
| 17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | |
| 16964243 | 2006 | A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | |
| 16421571 | 2006 | DNA sequence and analysis of human chromosome 8. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15060142 | 2004 | Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12880961 | 2003 | Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11114193 | 2000 | Functional genomics reveals a family of eukaryotic oxidation protection genes. | |
| 8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. |
