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Tbio Homeobox protein orthopedia

Probably involved in the differentiation of hypothalamic neuroendocrine cells.

This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 187.70
PubTator Score 25.69

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
lung carcinoma 2843 2.0e-65
adult high grade glioma 3801 1.3e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.5
Disease Target Count Z-score Confidence
Skull base meningioma 3 4.098 2.0
Opioid abuse 5 3.602 1.8

Expression

  Differential Expression (2)

Disease log2 FC p
adult high grade glioma 1.400 1.3e-03
lung carcinoma 3.900 2.0e-65

Synonym

Accession Q5XKR4
Symbols

Gene

OTP

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (10)

 GO Function (1)

 GO Component (1)

 GO Process (6)

 Compartment GO Term (14)

 MGI Phenotype (4)

 GWAS Trait (1)

 HCA RNA Cell Line (28)

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Gene RIF (3)

AA Sequence 

MLSHADLLDARLGMKDAAELLGHREAVKCRLGVGGSDPGGHPGDLAPNSDPVEGATLLPGEDITTVGSTP      1 - 70
ASLAVSAKDPDKQPGPQGGPNPSQAGQQQGQQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALR     71 - 140
IGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTPGLPQFPSAAAAAAAAMGDSLCSFHANDTRWA    141 - 210
AAAMPGVSQLPLPPALGRQQAMAQSLSQCSLAAGPPPNSMGLSNSLAGSNGAGLQSHLYQPAFPGMVPAS    211 - 280
LPGPSNVSGSPQLCSSPDSSDVWRGTSIASLRRKALEHTVSMSFT                             281 - 325
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Text Mined References (6)

PMID Year Title