Tdark | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial |
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Comments
Disease | Target Count | P-value |
---|---|---|
oligodendroglioma | 2850 | 3.8e-15 |
pituitary cancer | 1972 | 2.7e-05 |
group 3 medulloblastoma | 4104 | 7.1e-05 |
medulloblastoma, large-cell | 6241 | 9.9e-05 |
primitive neuroectodermal tumor | 3035 | 7.2e-04 |
gastric cancer | 459 | 1.6e-03 |
Rheumatoid arthritis | 1191 | 3.0e-03 |
lung cancer | 4740 | 5.3e-03 |
osteosarcoma | 7950 | 1.1e-02 |
intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.3e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Loeys-Dietz syndrome | 23 | 4.576 | 2.3 |
Ehlers-Danlos syndrome | 43 | 3.961 | 2.0 |
Disease | log2 FC | p |
---|---|---|
gastric cancer | 1.100 | 1.6e-03 |
group 3 medulloblastoma | 1.400 | 7.1e-05 |
intraductal papillary-mucinous adenoma (... | 1.100 | 4.3e-02 |
lung cancer | 1.100 | 5.3e-03 |
medulloblastoma, large-cell | 1.100 | 9.9e-05 |
oligodendroglioma | 1.100 | 3.8e-15 |
osteosarcoma | 1.133 | 1.1e-02 |
pituitary cancer | 1.100 | 2.7e-05 |
primitive neuroectodermal tumor | 1.200 | 7.2e-04 |
Rheumatoid arthritis | -1.200 | 3.0e-03 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG |
MLILTKTAGVFFKPSKRKVYEFLRSFNFHPGTLFLHKIVLGIETSCDDTAAAVVDETGNVLGEAIHSQTE 1 - 70 VHLKTGGIVPPAAQQLHRENIQRIVQEALSASGVSPSDLSAIATTIKPGLALSLGVGLSFSLQLVGQLKK 71 - 140 PFIPIHHMEAHALTIRLTNKVEFPFLVLLISGGHCLLALVQGVSDFLLLGKSLDIAPGDMLDKVARRLSL 141 - 210 IKHPECSTMSGGKAIEHLAKQGNRFHFDIKPPLHHAKNCDFSFTGLQHVTDKIIMKKEKEEGIEKGQILS 211 - 280 SAADIAATVQHTMACHLVKRTHRAILFCKQRDLLPQNNAVLVASGGVASNFYIRRALEILTNATQCTLLC 281 - 350 PPPRLCTDNGIMIAWNGIERLRAGLGILHDIEGIRYEPKCPLGVDISKEVGEASIKVPQLKMEI 351 - 414 //