| Tdark | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial |
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2850 | 3.8e-15 |
| pituitary cancer | 1972 | 2.7e-05 |
| group 3 medulloblastoma | 4104 | 7.1e-05 |
| medulloblastoma, large-cell | 6241 | 9.9e-05 |
| primitive neuroectodermal tumor | 3035 | 7.2e-04 |
| gastric cancer | 459 | 1.6e-03 |
| Rheumatoid arthritis | 1191 | 3.0e-03 |
| lung cancer | 4740 | 5.3e-03 |
| osteosarcoma | 7950 | 1.1e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Loeys-Dietz syndrome | 23 | 4.576 | 2.3 |
| Ehlers-Danlos syndrome | 43 | 3.961 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| gastric cancer | 1.100 | 1.6e-03 |
| group 3 medulloblastoma | 1.400 | 7.1e-05 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 4.3e-02 |
| lung cancer | 1.100 | 5.3e-03 |
| medulloblastoma, large-cell | 1.100 | 9.9e-05 |
| oligodendroglioma | 1.100 | 3.8e-15 |
| osteosarcoma | 1.133 | 1.1e-02 |
| pituitary cancer | 1.100 | 2.7e-05 |
| primitive neuroectodermal tumor | 1.200 | 7.2e-04 |
| Rheumatoid arthritis | -1.200 | 3.0e-03 |
MLILTKTAGVFFKPSKRKVYEFLRSFNFHPGTLFLHKIVLGIETSCDDTAAAVVDETGNVLGEAIHSQTE 1 - 70 VHLKTGGIVPPAAQQLHRENIQRIVQEALSASGVSPSDLSAIATTIKPGLALSLGVGLSFSLQLVGQLKK 71 - 140 PFIPIHHMEAHALTIRLTNKVEFPFLVLLISGGHCLLALVQGVSDFLLLGKSLDIAPGDMLDKVARRLSL 141 - 210 IKHPECSTMSGGKAIEHLAKQGNRFHFDIKPPLHHAKNCDFSFTGLQHVTDKIIMKKEKEEGIEKGQILS 211 - 280 SAADIAATVQHTMACHLVKRTHRAILFCKQRDLLPQNNAVLVASGGVASNFYIRRALEILTNATQCTLLC 281 - 350 PPPRLCTDNGIMIAWNGIERLRAGLGILHDIEGIRYEPKCPLGVDISKEVGEASIKVPQLKMEI 351 - 414 //
