Tbio ORC1 Origin recognition complex subunit 1

Protein Summary

Description

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q13415
• D3DQ34
• Q13471
• Q5T0F5

Gene Name

• ORC1

Ensembl ID

• ENST00000371566
• ENSP00000360621
• ENSG00000085840
• ENST00000371568
• ENSP00000360623

Symbol

• ORC1L
• PARC1
• ORC1L
• PARC1
• HSORC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.96
histone modification site profile	0.93
molecular function	0.86
gene perturbation	0.85
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Origin Recognition Complex Subunit 1

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Replication Origin Binding Protein / Origin Recognition Complex Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.03   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 196   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.03   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0