| Tbio | Optineurin |
(Microbial infection) May constitute a cellular target for adenovirus E3 14.7 and Bluetongue virus protein NS3 to inhibit innate immune response.
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amyotrophic lateral sclerosis | 451 | 5.165 | 2.6 |
| AMYOTROPHIC LATERAL SCLEROSIS 12 | 1 | 0.0 | 0.0 |
| GLAUCOMA, NORMAL TENSION, SUSCEPTIBILITY TO | 2 | 0.0 | 0.0 |
| Glaucoma, Open-Angle | 11 | 0.0 | 0.0 |
| Osteitis Deformans | 11 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 9.9e-10 |
| malignant mesothelioma | 3232 | 1.9e-07 |
| glioblastoma | 5792 | 3.7e-07 |
| medulloblastoma, large-cell | 6241 | 1.6e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.8e-06 |
| psoriasis | 6694 | 8.0e-06 |
| ovarian cancer | 8520 | 1.3e-05 |
| adult high grade glioma | 3801 | 1.4e-04 |
| acute quadriplegic myopathy | 1158 | 2.3e-04 |
| group 3 medulloblastoma | 4104 | 5.8e-04 |
| primitive neuroectodermal tumor | 3035 | 6.0e-04 |
| ductal carcinoma in situ | 1745 | 2.6e-03 |
| ependymoma | 4679 | 6.6e-03 |
| lung cancer | 4740 | 1.2e-02 |
| colon cancer | 1478 | 1.2e-02 |
| astrocytic glioma | 2597 | 1.8e-02 |
| acute myeloid leukemia | 783 | 2.7e-02 |
| oligodendroglioma | 2850 | 3.1e-02 |
| spina bifida | 1074 | 4.0e-02 |
| osteosarcoma | 7950 | 4.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Paget's disease of bone | 36 | 4.067 | 2.0 |
| Disease | Target Count |
|---|---|
| amyotrophic lateral sclerosis type 12 | 1 |
| primary open angle glaucoma | 16 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -1.700 | 2.7e-02 |
| acute quadriplegic myopathy | -1.051 | 2.3e-04 |
| adult high grade glioma | -1.800 | 1.4e-04 |
| astrocytic glioma | -1.100 | 1.8e-02 |
| atypical teratoid / rhabdoid tumor | -1.400 | 6.8e-06 |
| colon cancer | -1.500 | 1.2e-02 |
| ductal carcinoma in situ | -1.300 | 2.6e-03 |
| ependymoma | -2.100 | 6.6e-03 |
| glioblastoma | -1.700 | 3.7e-07 |
| group 3 medulloblastoma | -1.700 | 5.8e-04 |
| lung cancer | -1.300 | 1.2e-02 |
| malignant mesothelioma | -2.600 | 1.9e-07 |
| medulloblastoma, large-cell | -3.500 | 1.6e-06 |
| non-small cell lung cancer | -1.050 | 9.9e-10 |
| oligodendroglioma | -1.700 | 3.1e-02 |
| osteosarcoma | -1.470 | 4.1e-02 |
| ovarian cancer | -1.900 | 1.3e-05 |
| primitive neuroectodermal tumor | -1.100 | 6.0e-04 |
| psoriasis | -1.100 | 8.0e-06 |
| spina bifida | -1.624 | 4.0e-02 |
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFE 1 - 70 ELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEK 71 - 140 DQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTA 141 - 210 LSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEG 211 - 280 STEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSKAELMKKRLQEKCQALERKNSAIPSELNE 281 - 350 KQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 351 - 420 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKE 421 - 490 QLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGE 491 - 560 VLPDIDTLQIHVMDCII 561 - 577 //
