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Tdark Olfactomedin-like protein 2B


 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 1.09
PubTator Score 0.13

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Heart conduction disease 65 0.0 2.0
Disease Target Count Z-score Confidence
Hyperuricemia 35 3.113 1.6

Expression

  Differential Expression (18)

Disease log2 FC p
glioblastoma multiforme 1.100 7.9e-07
osteosarcoma 2.219 1.2e-02
cystic fibrosis -3.240 1.8e-07
Duchenne muscular dystrophy 1.767 4.8e-10
autosomal dominant Emery-Dreifuss muscul... 1.003 2.9e-02
Becker muscular dystrophy 1.236 7.4e-04
juvenile dermatomyositis 1.161 3.7e-08
limb girdle muscular dystrophy 2A 1.061 3.2e-04
primary pancreatic ductal adenocarcinoma 3.137 3.0e-04
pancreatic cancer 2.800 4.3e-04
diabetes mellitus -1.300 2.9e-02
interstitial cystitis 1.700 1.6e-04
invasive ductal carcinoma 1.740 8.1e-03
Breast cancer 1.300 6.0e-03
gastric carcinoma 2.100 4.5e-02
ulcerative colitis 1.100 2.0e-02
ovarian cancer 1.200 1.4e-02
head and neck cancer -1.100 4.4e-02

Synonym

Accession Q68BL8 B7ZA39 Q5VU96 Q6NX46 Q86X11 Q9Y3X6
Symbols

Gene

OLFML2B

PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (9)

 GO Component (1)

 Compartment GO Term (3)

 GWAS Trait (2)

 HCA RNA Cell Line (54)

See all...

 CSPA Cell Line (1)

Pathway (1)

Protein-protein Interaction (5)

DNAJC3   HSPA5   CHSY1   LONP2   ERF  

Gene RIF (3)

PMID Text
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19948975 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
18976975 Knockdown of olfactomedin-like 2B (OLFML2B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells

AA Sequence 

MAKPRLLVLYFALIVVPAWVSSIVLTGTSEPPDAQTVAPAEDETLQNEADNQENVLSQLLGDYDKVKAMS      1 - 70
EGSDCQCKCVVRPLGRDACQRINAGASRKEDFYTVETITSGSSCKCACVAPPSALNPCEGDFRLQKLREA     71 - 140
DSQDLKLSTIIDMLEGAFYGLDLLKLHSVTTKLVGRVDKLEEEVSKNLTKENEQIKEDMEEIRTEMNKRG    141 - 210
KENCSENILDSMPDIRSALQRDAAAAYAHPEYEERFLQEETVSQQINSIELLQTRPLALPEVVKSQRPLQ    211 - 280
RQVHLRGRPASQPTVIRGITYYKAKVSEEENDIEEQQDEFFSGDNGVDLLIEDQLLRHNGLMTSVTRRPA    281 - 350
ATRQGHSTAVTSDLNARTAPWSSALPQPSTSDPSIANHASVGPTLQTTSVSPDPTRESVLQPSPQVPATT    351 - 420
VAHTATQQPAAPAPPAVSPREALMEAMHTVPVPPTTVRTDSLGKDAPAGWGTTPASPTLSPEEEDDIRNV    421 - 490
IGRCKDTLSTITGPTTQNTYGRNEGAWMKDPLAKDERIYVTNYYYGNTLVEFRNLENFKQGRWSNSYKLP    491 - 560
YSWIGTGHVVYNGAFYYNRAFTRNIIKYDLKQRYVAAWAMLHDVAYEEATPWRWQGHSDVDFAVDENGLW    561 - 630
LIYPALDDEGFSQEVIVLSKLNAADLSTQKETTWRTGLRRNFYGNCFVICGVLYAVDSYNQRNANISYAF    631 - 700
DTHTNTQIVPRLLFENEYSYTTQIDYNPKDRLLYAWDNGHQVTYHVIFAY                        701 - 750
//

Text Mined References (11)

PMID Year Title
24952745 2014 Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
24324551 2013 Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
22939635 2012 Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19948975 2009 Integrative predictive model of coronary artery calcification in atherosclerosis.
19587794 2009 Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.