Tbio ODF3 Outer dense fiber protein 3

Protein Summary

Description

Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail. ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q96PU9
• B7ZLT0
• Q69YX0

Gene Name

• ODF3

Ensembl ID

• ENST00000325113
• ENSP00000325868
• ENSG00000177947
• ENST00000525282
• ENSP00000436588

Symbol

• SHIPPO1
• TISP50
• CT135
• TISP50
• SHIPPO1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
tissue sample	0.57
cell type or tissue	0.51
cell line	0.43
cellular component	0.42

Protein Classes

PANTHER Classes

Protein / Structural Protein / Outer Dense Fiber Protein 3

DTO Classes

Protein / Cellular Structure / Outer Dense Fiber Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.95   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.95   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0