Tbio OBSCN Obscurin

Protein Summary

Description

Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5VST9
• Q2A664
• Q5T7G8
• Q5T7G9
• Q5VSU2
• Q86YC7
• Q8NHN0
• Q8NHN1
• Q8NHN2
• Q8NHN3
• Q8NHN4
• Q8NHN5
• Q8NHN6
• Q8NHN7
• Q8NHN8
• Q8NHN9
• Q96AA2
• Q9HCD3
• Q9HCL6

Gene Name

• OBSCN

Ensembl ID

• ENST00000284548
• ENSP00000284548
• ENSG00000154358
• ENST00000422127
• ENSP00000409493
• ENST00000636875
• ENSP00000490900

Symbol

• KIAA1556
• KIAA1639
• UNC89
• ARHGEF30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
cell line	0.72
virus perturbation	0.68
biological process	0.64

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Trio Family / Obscurin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.14   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.14   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0