| Tbio | Protein phosphatase 1 regulatory subunit 17 |
Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.
The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypercholesterolemia, Familial | 23 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Hyperlipoproteinemia Type IIa | 11 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 5.0e-06 |
| tuberculosis | 2010 | 2.3e-05 |
| pituitary cancer | 1972 | 2.8e-03 |
| ependymoma | 4679 | 4.4e-03 |
| Disease | log2 FC | p |
|---|---|---|
| ependymoma | -1.100 | 4.4e-03 |
| lung carcinoma | 1.600 | 5.0e-06 |
| pituitary cancer | -1.200 | 2.8e-03 |
| tuberculosis | -2.100 | 2.3e-05 |
