Property Summary

NCBI Gene PubMed Count 48
PubMed Score 97.43
PubTator Score 69.89

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
pilocytic astrocytoma 3086 4.98013917038387E-8
osteosarcoma 7933 1.6084739686502E-6
glioblastoma 5572 1.20241368471632E-5
psoriasis 6685 1.30410000197448E-4
posterior fossa group A ependymoma 1511 1.69370700441201E-4
ulcerative colitis 2087 2.85503350425237E-4
interstitial cystitis 2299 4.27453191418004E-4
adult high grade glioma 2148 5.70437411648496E-4
head and neck cancer and chronic obstructive pulmonary disease 237 0.00515741036032343
chronic rhinosinusitis 512 0.0375144287146728
Disease Target Count Z-score Confidence
adult-onset Still's disease 6 3.485 1.7


  Differential Expression (10)

Disease log2 FC p
psoriasis -2.000 0.000
osteosarcoma -1.112 0.000
glioblastoma 1.100 0.000
interstitial cystitis 2.100 0.000
adult high grade glioma 1.600 0.001
pilocytic astrocytoma 2.100 0.000
posterior fossa group A ependymoma 1.300 0.000
ulcerative colitis 1.200 0.000
chronic rhinosinusitis 1.004 0.038
head and neck cancer and chronic obstruc... 1.300 0.005


Accession O95998 B3KUZ0 B7WPK4 O95993 O96027 Q9NZA9 Q9UBR7 IL-18BP
Symbols IL18BPa


  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG

Gene RIF (35)

25807634 imbalance of IL-18/IL-18BP ratio in IgA nephropathy especially in patients with arteriolar lesions
25548255 The natural IL-18 inhibitor IL-18BP further regulates IL-18 activity in the extracellular environment. Review.
24963217 IL-18, IL-18BP, and IL-18R may have roles in the pathogenesis of epithelial ovarian carcinoma
24478434 HPV16 E7 oncoprotein increases production of the IL18BP in keratinocytes.
23873689 these data indicate that IL-18BP, which is produced in EOC in response to microenvironmental factors, may inhibit endogenous or exogenous IL-18 activity
23419721 Data suggest that the imbalance of IL-18/IL-18BP might play an important role in the pathogenesis of systemic juvenile idiopathic arthritis (SJIA) and it might go hand-in-hand with the severity of SJIA.
22913567 Due to highly significant increases in circulating IL-18BP in schizophrenia compared to controls, the levels of free IL-18 are not significantly different between schizophrenic groups.
22289535 The balance between interleukin-18 (IL-18) and its endogenous antagonist, IL-18 binding protein (IL-18BP), was evaluated in children with Henoch-Schonlein purpura.
21867627 Imbalance between IL-18 and IL-18BP may play an important role in pathogenesis of idiopathic thrombocytopenic purpura.
21656327 High IL-18 BP levels indicate the severity of existing glomerular injury in systemic lupus erythematosus.

AA Sequence


Text Mined References (50)

PMID Year Title
25807634 2015 Imbalance of interleukin-18 and interleukin-18 binding protein in patients with IgA nephropathy implicating renal vasculopathy.
25548255 2015 Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP.
24963217 2014 Expression of IL-18, IL-18 binding protein, and IL-18 receptor by normal and cancerous human ovarian tissues: possible implication of IL-18 in the pathogenesis of ovarian carcinoma.
24478434 2014 Human papillomavirus E7 oncoprotein increases production of the anti-inflammatory interleukin-18 binding protein in keratinocytes.
23873689 2013 The IL-18 antagonist IL-18-binding protein is produced in the human ovarian cancer microenvironment.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23419721 2013 The imbalance of IL-18/IL-18BP in patients with systemic juvenile idiopathic arthritis.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22913567 2012 Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia.
22289535 2011 Imbalance of interleukin-18 and interleukin-18 binding protein in children with Henoch-Schönlein purpura.