Tbio AGR2 Anterior gradient protein 2 homolog

Protein Summary

Description

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• O95994
• AG-2

Gene Name

• AGR2

Ensembl ID

• ENST00000419304
• ENSP00000391490
• ENSG00000106541

Symbol

• AG2
• AG2
• AG-2
• HPC8
• GOB-4
• HAG-2
• XAG-2
• PDIA17
• HEL-S-116

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
transcription factor perturbation	0.88
gene perturbation	0.84
biological term	0.66
small molecule perturbation	0.65

Protein Classes

PANTHER Classes

Protein / Surfactant / Anterior Gradient Protein 2 Homolog

Protein / Oxidoreductase / Reductase / Anterior Gradient Protein 2 Homolog

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Anterior Gradient Protein 2 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.34   (req: < 5)

Gene RIFs: 132   (req: <= 3)

Antibodies: 768   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.34   (req: >= 5)

Gene RIFs: 132   (req: > 3)

Antibodies: 768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0