Property Summary

NCBI Gene PubMed Count 20
PubMed Score 31.14
PubTator Score 16.58

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 3.35226616723653E-52
non-small cell lung cancer 2798 7.97266851549837E-10
malignant mesothelioma 3163 1.05016736930117E-6
pilocytic astrocytoma 3086 1.5903689363408E-6
lung cancer 4473 6.79564589304157E-6
nasopharyngeal carcinoma 1056 1.69849554473479E-5
adrenocortical carcinoma 1427 8.71524586297045E-5
oligodendroglioma 2849 1.01570792531155E-4
lung carcinoma 2844 1.82708854446152E-4
primary Sjogren syndrome 789 2.86835834981357E-4
cutaneous lupus erythematosus 1056 3.52722408911065E-4
pituitary cancer 1972 6.02922907391596E-4
non-inflammatory breast cancer 208 6.46372826815362E-4
Atopic dermatitis 944 6.98935553997334E-4
cystic fibrosis 1670 9.55150912980986E-4
tuberculosis and treatment for 3 months 327 0.00101958980368167
ulcerative colitis 2087 0.00145864657831497
posterior fossa group A ependymoma 1511 0.00178806237998624
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00307233124409265
primary pancreatic ductal adenocarcinoma 1271 0.00371502711529036
pancreatic cancer 2300 0.00754414575447454
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00831492897406558
group 3 medulloblastoma 2254 0.00972317275806151
chronic rhinosinusitis 512 0.0307840601221068
aldosterone-producing adenoma 664 0.0323001600546486
astrocytoma 1493 0.0327741895592767
ductal carcinoma in situ 1745 0.0344938489721485
Disease Target Count Z-score Confidence
Lassa fever 10 3.045 1.5



Accession O95992 B2RBY3
Symbols C25H


PANTHER Protein Class (2)

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
Zebrafish OMA Inparanoid
C. elegans OMA EggNOG Inparanoid

Gene RIF (17)

26857497 Exome analysis in 212 multiple sclerosis and 14 neuromyelitis optica patients identified a rare CH25H p.Q17H mutation in two NMO patients of Asian ancestry. In addition, association analysis of common CH25H variants.
26469385 HIV-1 MA increases CH25H mRNA expression in HepG2 cells
25999047 Infection with HCV causes up-regulation of interferon-inducible CH25H in vivo.
25903345 These results demonstrate that CH25H constitutes a primary innate response against hepatitis C virus infection through regulating host lipid metabolism.
24667918 HIV-1 MA increases CH25H mRNA expression in HepG2 cells
20699362 Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.
20574532 Observational study of gene-disease association. (HuGE Navigator)
20535486 Observational study of gene-disease association. (HuGE Navigator)
20534741 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20413850 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence


Text Mined References (21)

PMID Year Title
26857497 2016 Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
25999047 2015 Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
25903345 2015 Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
21041692 2010 Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.
20699362 2010 Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.
20574532 2010 Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
20535486 2010 Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.
20534741 2010 Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
20445134 2010 Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
20413850 2010 Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.