Property Summary

NCBI Gene PubMed Count 129
PubMed Score 326.05
PubTator Score 305.49

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count
Colorectal Neoplasms 217
Lipoidosis 19
Disease Target Count P-value
psoriasis 6685 1.93556048243551E-44
breast carcinoma 1614 9.88415401809622E-12
pituitary cancer 1972 7.6805316496622E-8
Breast cancer 3099 1.02877648765065E-7
malignant mesothelioma 3163 3.03288036176885E-7
oligodendroglioma 2849 0.00116324233027692
astrocytic glioma 2241 0.00216972456540077
ependymoma 2514 0.00913308919296133
Hydrolethalus syndrome 128 0.0222045377471492
Disease Target Count Z-score Confidence
Obesity 616 3.587 1.8
diabetes mellitus 1663 3.499 1.7


  Differential Expression (9)

Disease log2 FC p
malignant mesothelioma 2.100 0.000
astrocytic glioma 1.500 0.002
ependymoma 1.500 0.009
oligodendroglioma 1.900 0.001
psoriasis -3.400 0.000
Hydrolethalus syndrome -1.110 0.022
breast carcinoma 1.100 0.000
Breast cancer 3.700 0.000
pituitary cancer 1.400 0.000


Accession O95864 A8K2M6 B7Z634 Q6MZQ7 Q96H07 Q96SV8 Q9H3G3 Q9Y3X4
Symbols D6D


  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (113)

27004414 Single nucleotide polymorphisms in FADS gene (particularly rs174537) associate with plasma fatty acids and desaturase levels in patients with both type 2 diabetes and coronary artery disease.
26609056 We investigated the association of surgery-induced weight loss and FA desaturase (FADS)1/2 genotypes with serum and AT FA profile and with AT inflammation, measured as interleukin (IL)-1beta and NFkappaB pathway gene expression.
26513616 No associations were observed between any single-nucleotide polymorphisms and major depressive disorder diagnosis or attempted suicide status.
26474818 genetic association study in population of pregnant women in Republic of Seychelles: SNPs in FADS1/FADS2 are associated with maternal arachidonic acid status; a subtle association exists with neurodevelopment in this high fish-eating population. [REVIEW]
26455892 FADS2 has been shown to be important in the metabolism of polyunsaturated fatty acids.
26439440 FADS2 has been shown to be important in the metabolism of polyunsaturated fatty acids.
26277395 The enzyme C440A is also able to catalyse hydrolysis of FAD bound to the PAPS reductase domain, which is quantitatively converted into FMN.
26261632 Suggest that the FADS1 rs174546 SNP and the FADS2 rs174601 SNP are associated with the risk of coronary artery disease and ischemic stroke, and are likely to influence serum lipid levels.
26078250 fatty acid desaturase 2 index was associated with child cognitive function in Indonesia
26065859 results demonstrate that the FADS2 classical transcript mediates direct Delta4 desaturation to yield 22:6n-3 and 22:5n-6 in human cells

AA Sequence

RALLDIIRSLKKSGKLWLDAYLHK                                                  421 - 444

Text Mined References (134)

PMID Year Title
27004414 2016 Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.
26609056 2016 FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue.
26513616 2016 Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior.
26474818 2015 Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.
26455892 2015 Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance.
26439440 2015 Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part I: maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: an exploratory analysis.
26277395 2015 Human FAD synthase is a bi-functional enzyme with a FAD hydrolase activity in the molybdopterin binding domain.
26261632 2015 Association of two polymorphisms in the FADS1/FADS2 gene cluster and the risk of coronary artery disease and ischemic stroke.
26078250 2015 Genetic variants of FADS gene cluster, plasma LC-PUFA levels and the association with cognitive function of under-two-year-old Sasaknese Indonesian children.
26065859 2015 The fatty acid desaturase 2 (FADS2) gene product catalyzes ?4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells.