Tdark | Uridine diphosphate glucose pyrophosphatase |
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
pilocytic astrocytoma | 3086 | 1.67081508554189E-4 |
glioblastoma | 5572 | 7.55688523806973E-4 |
sonic hedgehog group medulloblastoma | 1482 | 0.0016243975891485 |
adult high grade glioma | 2148 | 0.00547475658743247 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Hard palate cancer | 11 | 3.633 | 1.8 |
Disease | log2 FC | p |
---|---|---|
glioblastoma | -1.100 | 0.001 |
sonic hedgehog group medulloblastoma | -1.400 | 0.002 |
adult high grade glioma | -1.300 | 0.005 |
pilocytic astrocytoma | -1.200 | 0.000 |
Accession | O95848 Q86SJ8 UDPG pyrophosphatase |
Symbols |
UGPP UGPPase |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Chicken | OMA Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Zebrafish | OMA EggNOG Inparanoid |
PMID | Year | Title |
---|---|---|
25416956 | 2014 | A proteome-scale map of the human interactome network. |
23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
21044950 | 2011 | Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
12620389 | 2003 | Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |
12508121 | 2003 | The DNA sequence and analysis of human chromosome 14. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
12429023 | 2003 | Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose. |
10662552 | 2000 | Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. |