| Tdark | Uridine diphosphate glucose pyrophosphatase |
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 1.6e-04 |
| glioblastoma | 5792 | 7.6e-04 |
| adult high grade glioma | 3801 | 5.5e-03 |
| group 4 medulloblastoma | 1855 | 1.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hard palate cancer | 10 | 3.645 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.300 | 5.5e-03 |
| Astrocytoma, Pilocytic | -1.200 | 1.6e-04 |
| glioblastoma | -1.100 | 7.6e-04 |
| group 4 medulloblastoma | -1.100 | 1.3e-02 |
