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  5. Uridine diphosphate glucose pyrophosphatase

Tdark Uridine diphosphate glucose pyrophosphatase

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 5.47
PubTator Score 4.84

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
Astrocytoma, Pilocytic 3081 1.6e-04
glioblastoma 5792 7.6e-04
adult high grade glioma 3801 5.5e-03
group 4 medulloblastoma 1855 1.3e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.5
Disease Target Count Z-score Confidence
Hard palate cancer 10 3.645 1.8

Expression

  Differential Expression (4)

Disease log2 FC p
adult high grade glioma -1.300 5.5e-03
Astrocytoma, Pilocytic -1.200 1.6e-04
glioblastoma -1.100 7.6e-04
group 4 medulloblastoma -1.100 1.3e-02

Synonym

Accession O95848 Q86SJ8 UDPG pyrophosphatase
Symbols UGPP
UGPPase

Gene

NUDT14

PANTHER Protein Class (2)

  Ortholog (10)

Species Source Disease
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (6)

 GO Function (3)

 GO Component (2)

 GO Process (1)

 Compartment GO Term (10)

 IMPC Phenotype (1)

 MGI Phenotype (1)

 HCA RNA Cell Line (55)

See all...

Pathway (6)

PDB (1)

Gene RIF (1)

AA Sequence 

MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNSSRRSLVLVKQFRPAVYAGEV      1 - 70
ERRFPGSLAAVDQDGPRELQPALPGSAGVTVELCAGLVDQPGLSLEEVACKEAWEECGYHLAPSDLRRVA     71 - 140
TYWSGVGLTGSRQTMFYTEVTDAQRSGPGGGLVEEGELIEVVHLPLEGAQAFADDPDIPKTLGVIFGVSW    141 - 210
FLSQVAPNLDLQ                                                              211 - 222
//

Text Mined References (11)

PMID Year Title