Property Summary

NCBI Gene PubMed Count 24
PubMed Score 23.76
PubTator Score 29.84

Knowledge Summary

Patent (3,733)


  Disease (2)

Disease Target Count
Short bowel syndrome 16
Disease Target Count P-value
breast carcinoma 1614 1.3e-03
fibroadenoma 557 4.4e-02


  Differential Expression (2)

Disease log2 FC p
breast carcinoma -1.100 1.3e-03
fibroadenoma -1.400 4.4e-02

Gene RIF (16)

24875097 Report gastrointestinal GLP-2 receptor and limited utility of GLP-2 in the management of inflammatory intestinal disorders.
22951144 GLP-2 receptors are highly expressed in gastrointestinal stromal tumors and Crohn's disease.
21326311 GLP2R encodes a G protein-coupled receptor and involved in proliferative and anti-apoptotic cellular responses.
21167157 docking studies were performed between the N-terminal extracellular domain of GLP-2 receptor and the GLP-2 hormone
20800603 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20468064 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19861958 Observational study of gene-disease association. (HuGE Navigator)
18829546 Sustained direct or indirect modulation of GLP-2R signaling does not modify intestinal tumor cell growth or survival.
16448646 Endogenously expressing GLP-2 receptor encoding mRNA and protein was identified in intestinal cell lines.
16401478 GLP-2-induced stimulation of blood flow is mediated by vasoactive neurotransmitters that are colocalized with GLP-2R in 2 functionally distinct cell types within the gastrointestinal tract
15817468 GLP-2 receptor C terminus has a role in modulating beta-arrestin-2 association but not ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation
15544847 GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth
15471943 glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways

AA Sequence


Text Mined References (25)

PMID Year Title
24990862 2014 The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis.
24875097 2014 Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.
22951144 2012 GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease.
21326311 2011 Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.
21167157 2011 Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain.
20800603 2010 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20468064 2010 Association study of 182 candidate genes in anorexia nervosa.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19861958 2010 Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.
18829546 2008 Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells.
18240029 2008 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
16448646 2006 Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines.
16401478 2006 GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.
15817468 2005 The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.
15670850 2005 Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.
15544847 2005 GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15471943 2005 The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11738243 2002 The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist.
11238747 2001 Glucagon-like peptide 2: a nutrient-responsive gut growth factor.
10982769 2000 Enteroendocrine localization of GLP-2 receptor expression in humans and rodents.
9990065 1999 Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.