Tchem MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4

Protein Summary

Description

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95819
• E7ESS2
• O75172
• Q9NST7

Gene Name

• MAP4K4

Ensembl ID

• ENST00000347699
• ENSP00000314363
• ENSG00000071054
• ENST00000350878
• ENSP00000343658
• ENST00000634702
• ENSP00000489579

Symbol

• HGK
• KIAA0687
• NIK
• HGK
• NIK
• MEKKK4
• FLH21957
• HEL-S-31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
molecular function	0.97
PubMedID	0.92
disease perturbation	0.87
hub protein	0.85

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Msn Subfamily / Mitogen-activated Protein Kinase Kinase Kinase Kinase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.07   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 632   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.07   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 105

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1