Protein Summary
May have an important role in the development and/or progression of some cancers. The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
- ENST00000370526
- ENSP00000359557
- ENSG00000182195
- BCUR1
- Mar7
- RTL7
- BCUR1
- Mart7
- SIRH7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.76 | ||
tissue sample | 0.69 | ||
histone modification site profile | 0.64 | ||
PubMedID | 0.54 | ||
transcription factor perturbation | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.91 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 187 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.91 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 187 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0