Tbio OXSR1 Serine/threonine-protein kinase OSR1

Protein Summary

Description

Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95747
• Q3LR53
• Q7Z501
• Q9UPQ1

Gene Name

• OXSR1

Ensembl ID

• ENST00000311806
• ENSP00000311713
• ENSG00000172939

Symbol

• KIAA1101
• OSR1
• OSR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.98
molecular function	0.98
virus perturbation	0.98
kinase perturbation	0.93

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Fray Subfamily / Serine/threonine-protein Kinase Osr1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.83   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 474   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.83   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0