Property Summary

NCBI Gene PubMed Count 21
PubMed Score 27.25
PubTator Score 20.92

Knowledge Summary

Patent (2,938)


  Disease Sources (2)

Disease Target Count P-value
atypical teratoid/rhabdoid tumor 1095 3.38113828602197E-13
posterior fossa group A ependymoma 1511 3.55369488805435E-10
pilocytic astrocytoma 3086 7.67106223978642E-10
group 3 medulloblastoma 2254 1.46272371490242E-6
primitive neuroectodermal tumor 3031 6.36309918479711E-6
medulloblastoma, large-cell 6234 5.38292980644942E-5
glioblastoma 5572 1.10324549525979E-4
pediatric high grade glioma 2712 4.19323341310764E-4
Down syndrome 548 5.42200983303322E-4
subependymal giant cell astrocytoma 2287 0.0161280580100521
Disease Target Count Z-score Confidence
Pain agnosia 99 3.772 1.9


  Differential Expression (10)


Accession O95665 Q53QQ5 Q57Z87 Q8IY58 Q8TBH6 NT-R-2
Symbols NTR2


PANTHER Protein Class (2)

  Ortholog (6)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid

  TechDev Info (1)

MLP Assay (2)

AID Type Active / Inconclusive / Inactive Description
588495 confirmatory 13 / 0 / 109 SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay
602334 confirmatory 20 / 0 / 67 SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2

Gene RIF (10)

26298774 high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells
23109725 NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells.
20468071 Observational study of gene-disease association. (HuGE Navigator)
20048080 NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+)
19968961 this study proposes a novel function of NTR2 in the regulation of NTR1 activity.
19874574 Observational study of gene-disease association. (HuGE Navigator)
19086053 Observational study of gene-disease association. (HuGE Navigator)
18624930 NTR1 and NTR2 mRNA were not detected in either pituitary adenomas or normal tissue.
15383539 ghrelin receptor, neurotensin receptor 2 and GPR39 display an unusually high degree of constitutive activity, determined by an aromatic cluster on the inner face of the extracellular ends of TMs VI and VII
11801734 Recycling ability depends on a single tyrosine residue

AA Sequence


Text Mined References (22)

PMID Year Title
26298774 2015 Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.
23109725 2012 Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.
20468071 2010 Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
20048080 2010 Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.
19968961 2010 Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors.
19874574 2009 Genetical genomic determinants of alcohol consumption in rats and humans.
19086053 2009 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
18624930 2008 Expression of neurotensin and its receptors in pituitary adenomas.
16754659 2006 Stable association between G alpha(q) and phospholipase C beta 1 in living cells.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.