CNOT4
CCR4-NOT transcription complex subunit 4
Protein Summary
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
- ENST00000315544
- ENSP00000326731
- ENSG00000080802
- ENST00000361528
- ENSP00000354673
- ENST00000414802
- ENSP00000416532
- ENST00000423368
- ENSP00000406777
- ENST00000428680
- ENSP00000399108
- ENST00000451834
- ENSP00000388491
- ENST00000541284
- ENSP00000445508
- NOT4
- NOT4
- NOT4H
- CLONE243
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.95 | ||
transcription factor perturbation | 0.94 | ||
transcription factor binding site profile | 0.93 | ||
virus perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.56 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 539 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.56 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 539 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0