Tbio DUS4L tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

Protein Summary

Description

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Uniprot Accession IDs

• O95620
• B4DLX0
• Q2NKK1

Gene Name

• DUS4L

Ensembl ID

• ENST00000265720
• ENSP00000265720
• ENSG00000105865
• ENST00000639937
• ENSP00000491438
• ENSG00000284103

Symbol

• DUS4
• PP35

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
cell type or tissue	0.68
transcription factor binding site profile	0.6
molecular function	0.56
transcription factor	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.21   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.21   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0