Tbio ACSL3 Long-chain-fatty-acid--CoA ligase 3

Protein Summary

Description

Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95573
• Q60I92
• Q8IUM9

Gene Name

• ACSL3

Ensembl ID

• ENST00000357430
• ENSP00000350012
• ENSG00000123983
• ENST00000392066
• ENSP00000375918

Symbol

• ACS3
• FACL3
• LACS3
• ACS3
• FACL3
• LACS3
• LACS 3
• PRO2194

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
virus perturbation	0.9
biological process	0.86
transcription factor binding site profile	0.83
microRNA	0.8

Protein Classes

PANTHER Classes

Protein / Ligase / Long-chain-fatty-acid--coa Ligase 3

DTO Classes

Protein / Enzyme / Ligase / Long-chain-fatty-acid--coa Ligase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.32   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.32   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0