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Tbio
PSMG1
Proteasome assembly chaperone 1

Protein Summary
Description
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331573
  • ENSP00000329915
  • ENSG00000183527
  • ENST00000380900
  • ENSP00000370286

Symbol
  • C21LRP
  • DSCR2
  • PAC1
  • PAC1
  • DSCR2
  • PAC-1
  • C21LRP
  • LRPC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.88
disease perturbation
0.87
transcription factor binding site profile
0.84
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.94   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.94   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0