| Tbio | Apolipoprotein M |
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
Comments
| Disease | Target Count |
|---|---|
| Adenocarcinoma of lung (disorder) | 48 |
| Malignant neoplasm of lung | 16 |
| Rheumatoid Arthritis | 1171 |
| Disease | Target Count | P-value |
|---|---|---|
| posterior fossa group B ependymoma | 1530 | 1.67365277631048E-11 |
| medulloblastoma | 1524 | 2.71930492427833E-8 |
| osteosarcoma | 7933 | 4.24318648501843E-7 |
| nephrosclerosis | 329 | 0.0147289347852697 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.0250994878691701 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Atherosclerosis | 275 | 3.778 | 1.9 |
| chronic kidney disease | 90 | 3.654 | 1.8 |
| Coronary artery disease | 240 | 3.274 | 1.6 |
| diabetes mellitus | 1663 | 3.187 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| nephrosclerosis | -1.806 | 0.015 |
| osteosarcoma | -1.824 | 0.000 |
| posterior fossa group B ependymoma | 1.500 | 0.000 |
| medulloblastoma | 1.200 | 0.000 |
| pancreatic ductal adenocarcinoma liver m... | -1.660 | 0.025 |
| Species | Source |
|---|---|
| Macaque | OMA Inparanoid |
| Mouse | OMA Inparanoid |
| Rat | OMA Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Pig | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 26642098 | ApoM is excreted in the urine of children after cardiac surgery in children with acute kidney injury |
| 26377577 | Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway. |
| 26057873 | these findings demonstrated that apoM suppressed TNF-alpha-induced expression of ICAM-1 and VCAM-1 through inhibiting the activity of NF-kappaB. |
| 25987835 | our findings present supportive evidence that ApoM is a regulator of human LRH-1 transcription, and further reveal the importance of ApoM as a critical regulator of bile acids metabolism |
| 25901639 | ApoM is highly expressed in renal proximal tubule cells and is usually reabsorbed by giantin-associated proteins in a process, which is also affected in kidney disease. |
| 25637426 | -724 I/D polymorphism decreases the apoM promoter activity, down-regulates the apoM protein expression level, and increases the risk of myocardial infarction |
| 25551802 | role of apoM in lipid metabolism and cardiometabolic diseases.(48-55) |
| 25194312 | Binary logistic regression analysis suggested that both apoM and apoAI mRNA may considered as independent risk factors for fetal macrosomia |
| 25187487 | Single nucleotide polymorphism in APOM is associated with lung cancer. |
| 25144649 | ApoM overexpression may have a potential role in improving insulin resistance in vivo and modulating apoM expression might be a future therapeutic strategy against insulin resistance in type 2 diabetes. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26642098 | 2016 | Urinary apolipoprotein M as a biomarker of acute kidney injury in children undergoing heart surgery. |
| 26377577 | 2015 | Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway. |
| 26057873 | 2015 | ApoM Suppresses TNF-?-Induced Expression of ICAM-1 and VCAM-1 Through Inhibiting the Activity of NF-?B. |
| 25987835 | 2015 | Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells. |
| 25901639 | 2015 | Apolipoprotein M: Research progress, regulation and metabolic functions (Review). |
| 25637426 | 2015 | Functional study of -724I/D polymorphism in apolipoprotein M (apoM) gene promoter region and its association with myocardial infarction. |
| 25551802 | 2015 | Apolipoprotein M in lipid metabolism and cardiometabolic diseases. |
| 25194312 | 2015 | Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia. |
| 25187487 | 2014 | Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. |
| 25144649 | 2014 | Intralipid decreases apolipoprotein M levels and insulin sensitivity in rats. |
| More... |
