Property Summary

NCBI Gene PubMed Count 91
PubMed Score 224.14
PubTator Score 126.57

Knowledge Summary


No data available


  Differential Expression (5)

Disease log2 FC p
nephrosclerosis -1.806 0.015
osteosarcoma -1.824 0.000
posterior fossa group B ependymoma 1.500 0.000
medulloblastoma 1.200 0.000
pancreatic ductal adenocarcinoma liver m... -1.660 0.025


Accession O95445 B0UX98 Q5SRP4 Q9P046 Q9UMP6 Apo-M
Symbols G3a



2WEW   2WEX   2YG2  

  Ortholog (10)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (78)

26642098 ApoM is excreted in the urine of children after cardiac surgery in children with acute kidney injury
26377577 Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway.
26057873 these findings demonstrated that apoM suppressed TNF-alpha-induced expression of ICAM-1 and VCAM-1 through inhibiting the activity of NF-kappaB.
25987835 our findings present supportive evidence that ApoM is a regulator of human LRH-1 transcription, and further reveal the importance of ApoM as a critical regulator of bile acids metabolism
25901639 ApoM is highly expressed in renal proximal tubule cells and is usually reabsorbed by giantin-associated proteins in a process, which is also affected in kidney disease.
25637426 -724 I/D polymorphism decreases the apoM promoter activity, down-regulates the apoM protein expression level, and increases the risk of myocardial infarction
25551802 role of apoM in lipid metabolism and cardiometabolic diseases.(48-55)
25194312 Binary logistic regression analysis suggested that both apoM and apoAI mRNA may considered as independent risk factors for fetal macrosomia
25187487 Single nucleotide polymorphism in APOM is associated with lung cancer.
25144649 ApoM overexpression may have a potential role in improving insulin resistance in vivo and modulating apoM expression might be a future therapeutic strategy against insulin resistance in type 2 diabetes.

AA Sequence


Text Mined References (93)

PMID Year Title
26642098 2016 Urinary apolipoprotein M as a biomarker of acute kidney injury in children undergoing heart surgery.
26377577 2015 Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway.
26057873 2015 ApoM Suppresses TNF-?-Induced Expression of ICAM-1 and VCAM-1 Through Inhibiting the Activity of NF-?B.
25987835 2015 Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells.
25901639 2015 Apolipoprotein M: Research progress, regulation and metabolic functions (Review).
25637426 2015 Functional study of -724I/D polymorphism in apolipoprotein M (apoM) gene promoter region and its association with myocardial infarction.
25551802 2015 Apolipoprotein M in lipid metabolism and cardiometabolic diseases.
25194312 2015 Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia.
25187487 2014 Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.
25144649 2014 Intralipid decreases apolipoprotein M levels and insulin sensitivity in rats.