Property Summary

NCBI Gene PubMed Count 14
PubMed Score 37.58
PubTator Score 99.43

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
pediatric high grade glioma 2712 1.43676667604419E-8
ovarian cancer 8492 3.36140087042824E-8
atypical teratoid / rhabdoid tumor 4369 3.51509876662023E-7
acute quadriplegic myopathy 1157 3.28783319185914E-6
glioblastoma 5572 4.52914645635568E-6
primitive neuroectodermal tumor 3031 2.03797764037532E-5
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0202382105765087



Accession O95415 D6W5R8 Q8WV52 Q9UIC6
Symbols I3


  Ortholog (9)

Gene RIF (5)

20538055 In the context of hepatocellular carcinoma cells, BRI3 is a target of WNT signaling.
19366692 BRI3 inhibits the various processing of amyloid protein precursor by blocking the access of alpha- and beta-secretases.
18452648 Possible roles of BRI3 in the process of neuronal differentiation.
17390049 BRI3 RNA is expressed less in stage 3 colon cancer in comparison to stage 2 colon cancer, and it is among 8 genes which can be used as a gene signature to differentiate colon cancer stages.
16508092 An X-ray data set was collected to 1.6 A resolution using synchrotron radiation, of a ligandin recombinant fusion protein.

AA Sequence


Text Mined References (14)

PMID Year Title
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
20538055 2010 Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.
19366692 2009 BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
18452648 2008 BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells.
17390049 2007 A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients.
16508092 2005 Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain.
16341674 2005 Transcriptome analysis of human gastric cancer.
15606899 2005 Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14592447 2003 bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death.