Tbio BRI3 Brain protein I3

Protein Summary

Description

Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).

Uniprot Accession IDs

• O95415
• D6W5R8
• Q8WV52
• Q9UIC6

Gene Name

• BRI3

Ensembl ID

• ENST00000297290
• ENSP00000297290
• ENSG00000164713

Symbol

• I3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
gene perturbation	0.76
tissue sample	0.74
small molecule perturbation	0.73
virus perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.62   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.62   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0