Tclin GDF11 Growth/differentiation factor 11

Protein Summary

Description

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• O95390
• Q9UID1
• Q9UID2
• GDF-11

Gene Name

• GDF11

Ensembl ID

• ENST00000257868
• ENSP00000257868
• ENSG00000135414

Symbol

• BMP11
• BMP11
• BMP-11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.73
protein domain	0.73
virus perturbation	0.72
phenotype	0.71
biological process	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Growth/differentiation Factor 11

DTO Classes

Protein / Signaling / Growth Factor / Growth/differentiation Factor 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.25   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.25   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1