Tbio WISP3 WNT1-inducible-signaling pathway protein 3

Protein Summary

Description

Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95389
• Q3KR29
• Q5H8W4
• Q6UXH6
• WISP-3

Gene Name

• WISP3

Ensembl ID

• ENST00000230529
• ENSP00000230529
• ENSG00000112761
• ENST00000361714
• ENSP00000354734
• ENST00000368666
• ENSP00000357655
• ENST00000604763
• ENSP00000473777

Symbol

• CCN6
• PPD
• LIBC
• PPAC
• WISP3
• WISP-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
protein domain	0.92
molecular function	0.6
biological term	0.54
co-expressed gene	0.52

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Wnt1-inducible-signaling Pathway Protein 3

DTO Classes

Protein / Signaling / Growth Factor / Wnt1-inducible-signaling Pathway Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.84   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.84   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0