MAP3K6
Mitogen-activated protein kinase kinase kinase 6
Protein Summary
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
- ENST00000357582
- ENSP00000350195
- ENSG00000142733
- ENST00000374040
- ENSP00000363152
- ENST00000493901
- ENSP00000419591
- ASK2
- MAPKKK6
- MEKK6
- ASK2
- MEKK6
- MAPKKK6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
protein domain | 0.92 | ||
gene perturbation | 0.88 | ||
transcription factor binding site profile | 0.79 | ||
histone modification site profile | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.4 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 201 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.4 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 201 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0