| Tbio | Tumor necrosis factor alpha-induced protein 8 |
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Juvenile | 126 | 0.0 | 0.0 |
| Esophageal Squamous Cell Carcinoma | 77 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Neoplasm Metastasis | 168 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Juvenile arthritis | 126 |
| Squamous cell carcinoma of esophagus | 77 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.1e-23 |
| ulcerative colitis | 1819 | 1.4e-06 |
| juvenile dermatomyositis | 1187 | 1.5e-06 |
| tuberculosis | 2010 | 1.7e-06 |
| ovarian cancer | 8520 | 2.0e-06 |
| ependymoma | 4679 | 3.4e-05 |
| Astrocytoma, Pilocytic | 3081 | 8.8e-05 |
| primary Sjogren syndrome | 735 | 1.0e-04 |
| psoriasis | 6694 | 3.2e-04 |
| glioblastoma | 5792 | 8.6e-04 |
| primitive neuroectodermal tumor | 3035 | 4.1e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.4e-03 |
| Waldenstrons macroglobulinemia | 765 | 8.2e-03 |
| sonic hedgehog group medulloblastoma | 467 | 9.3e-03 |
| osteosarcoma | 7950 | 9.6e-03 |
| lung cancer | 4740 | 1.0e-02 |
| Multiple myeloma | 1332 | 1.3e-02 |
| dermatomyositis | 966 | 1.3e-02 |
| adult high grade glioma | 3801 | 1.5e-02 |
| subependymal giant cell astrocytoma | 2287 | 2.6e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.8e-02 |
| sarcoidosis | 370 | 2.9e-02 |
| chronic kidney disease | 90 | 3.2e-02 |
| Bipolar Disorder | 666 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Plantar fasciitis | 8 | 3.45 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 1.5e-02 |
| Astrocytoma, Pilocytic | 1.100 | 8.8e-05 |
| atypical teratoid / rhabdoid tumor | 1.600 | 6.4e-03 |
| Bipolar Disorder | 1.314 | 4.4e-02 |
| chronic kidney disease | 1.600 | 3.2e-02 |
| dermatomyositis | 1.200 | 1.3e-02 |
| ependymoma | 1.100 | 3.4e-05 |
| glioblastoma | 1.100 | 8.6e-04 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 2.8e-02 |
| juvenile dermatomyositis | 1.034 | 1.5e-06 |
| lung cancer | -1.100 | 1.0e-02 |
| lung carcinoma | -1.400 | 1.1e-23 |
| Multiple myeloma | 1.641 | 1.3e-02 |
| osteosarcoma | -1.470 | 9.6e-03 |
| ovarian cancer | -2.700 | 2.0e-06 |
| primary Sjogren syndrome | 2.300 | 1.0e-04 |
| primitive neuroectodermal tumor | 1.200 | 4.1e-03 |
| psoriasis | 1.500 | 3.2e-04 |
| sarcoidosis | 1.400 | 2.9e-02 |
| sonic hedgehog group medulloblastoma | 1.300 | 9.3e-03 |
| subependymal giant cell astrocytoma | 2.044 | 2.6e-02 |
| tuberculosis | -1.700 | 1.7e-06 |
| ulcerative colitis | 2.100 | 1.4e-06 |
| Waldenstrons macroglobulinemia | 1.484 | 8.2e-03 |
