Tbio TNFAIP8 Tumor necrosis factor alpha-induced protein 8

Protein Summary

Description

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

Uniprot Accession IDs

• O95379
• B3KMH1
• B3KMI2
• B7Z713
• Q9P1Q1
• Q9UER5
• Q9UP47
• TNF alpha-induced protein 8

Gene Name

• TNFAIP8

Ensembl ID

• ENST00000274456
• ENSP00000274456
• ENSG00000145779
• ENST00000503646
• ENSP00000421848
• ENST00000504771
• ENSP00000422245
• ENST00000513374
• ENSP00000427424

Symbol

• NDED
• GG2-1
• SCCS2
• SCC-S2
• MDC-3.13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
PubMedID	0.91
kinase perturbation	0.88
interacting protein	0.85
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.76   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.76   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0