| Tbio | Tumor necrosis factor alpha-induced protein 8 |
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Comments
Property Summary
| NCBI Gene PubMed Count | 28 |
| Grant Count | 5 |
| R01 Count | 5 |
| Funding | $383,630.2 |
| PubMed Score | 38.45 |
| PubTator Score | 31.95 |
| Disease | log2 FC | p |
|---|---|---|
| Waldenstrons macroglobulinemia | 1.644 | 0.006 |
| Multiple myeloma | 1.836 | 0.010 |
| psoriasis | 1.700 | 0.000 |
| glioblastoma | 1.900 | 0.003 |
| osteosarcoma | -3.793 | 0.000 |
| posterior fossa group A ependymoma | 1.600 | 0.000 |
| atypical teratoid / rhabdoid tumor | 1.600 | 0.006 |
| primitive neuroectodermal tumor | 1.200 | 0.004 |
| juvenile dermatomyositis | 1.034 | 0.000 |
| chronic kidney disease | 1.700 | 0.036 |
| tuberculosis | -1.700 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 0.028 |
| lung cancer | -1.800 | 0.000 |
| sarcoidosis | 1.500 | 0.032 |
| pediatric high grade glioma | 1.200 | 0.001 |
| pilocytic astrocytoma | 1.300 | 0.000 |
| sonic hedgehog group medulloblastoma | 1.600 | 0.004 |
| primary Sjogren syndrome | 2.300 | 0.000 |
| subependymal giant cell astrocytoma | 2.044 | 0.026 |
| lung carcinoma | -1.400 | 0.000 |
| Bipolar Disorder | 1.314 | 0.044 |
| ulcerative colitis | 2.400 | 0.000 |
| ovarian cancer | -3.100 | 0.000 |
| dermatomyositis | 1.200 | 0.013 |
| PMID | Text |
|---|---|
| 25936980 | Expression of TNFAIP8 is up-regulated in human gastric cancer and regulates cell proliferation, invasion and migration. |
| 24767861 | our findings indicate that TNFAIP8 overexpression is an independent predictor of platinum resistance in epithelial ovarian cancer |
| 24621012 | Our data suggest that TNFAIP8 overexpression may contribute to lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma. |
| 24590269 | TNFAIP8 may be used as a prognostic marker for the recurrence of endometrial cancer (EC), and its promotion of the proliferation and metastasis in EC may be due to its mediation of Ki-67 and MMP9. |
| 24464924 | SCC-S2 may play roles in affecting both immune cells and tumor cells in the thyroid and may indicate a novel pathway for understanding the pathogenesis of the disease. |
| 24162774 | HIV-1 gp120 upregulates the expression of tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) in human B cells |
| 24136748 | These results provide evidence that TNFAIP8 plays critical roles in non-small cell lung cancer |
| 23299407 | the TNFAIP8-rs11064 Single nucleotide polymorphism may function by affecting the affinity of miR-22 binding to the 3'-untranslated region of TNFAIP8 and regulating TNFAIP8 expression, thus contributing to cervical cancer risk |
| 23280553 | TNFAIP8 functions in oncogenesis are likely to involve activation of the integrin, MMP and VEGFR-2 signaling pathways. TNFAIP8 expression revealed correlation of both cytoplasmic and nuclear TNFAIP8 overexpression with high grade prostatic adenocarcinomas |
| 22886548 | SCC-S2 is overexpressed in colon cancers. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 25936980 | 2015 | Expression of tumor necrosis factor ?-induced protein 8 is upregulated in human gastric cancer and regulates cell proliferation, invasion and migration. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25130324 | 2014 | A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. |
| 24767861 | 2014 | TNFAIP8 overexpression is associated with platinum resistance in epithelial ovarian cancers with optimal cytoreduction. |
| 24621012 | 2014 | TNFAIP8 overexpression is associated with lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma. |
| 24590269 | 2014 | Correlation of TNFAIP8 overexpression with the proliferation, metastasis, and disease-free survival in endometrial cancer. |
| 24464924 | 2014 | Upregulation of SCC-S2 in immune cells and tumor tissues of papillary thyroid carcinoma. |
| 24136748 | 2014 | Variance of TNFAIP8 expression between tumor tissues and tumor-infiltrating CD4+ and CD8+ T cells in non-small cell lung cancer. |
| 23299407 | 2013 | Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes. |
| More... |
