Property Summary

NCBI Gene PubMed Count 28
PubMed Score 38.45
PubTator Score 31.95

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 1.05452690437873E-23
osteosarcoma 7933 6.74984998854754E-12
ovarian cancer 8492 4.67629099126819E-7
ulcerative colitis 2087 1.08703129329523E-6
juvenile dermatomyositis 1189 1.47310671547012E-6
tuberculosis 1563 1.69802843740939E-6
posterior fossa group A ependymoma 1511 8.10724477720093E-6
lung cancer 4473 2.27274667856812E-5
psoriasis 6685 7.12919376150728E-5
pilocytic astrocytoma 3086 8.18674360635632E-5
primary Sjogren syndrome 789 9.99979885911526E-5
pediatric high grade glioma 2712 5.14627571506021E-4
glioblastoma 5572 0.00283187729036429
sonic hedgehog group medulloblastoma 1482 0.00401144916745825
primitive neuroectodermal tumor 3031 0.00409822261776416
Waldenstrons macroglobulinemia 765 0.00589213762886973
atypical teratoid / rhabdoid tumor 4369 0.00644194628059635
Multiple myeloma 1328 0.0101453759627331
dermatomyositis 967 0.01339117181267
subependymal giant cell astrocytoma 2287 0.026109381287536
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0278424596508951
sarcoidosis 368 0.0319817664440082
chronic kidney disease 90 0.0356099858680912
Bipolar Disorder 266 0.0440774084320834
Disease Target Count Z-score Confidence
Cancer 2346 3.043 1.5



Accession O95379 B3KMH1 B3KMI2 B7Z713 Q9P1Q1 Q9UER5 Q9UP47 TNF alpha-induced protein 8
Symbols NDED


  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (16)

25936980 Expression of TNFAIP8 is up-regulated in human gastric cancer and regulates cell proliferation, invasion and migration.
24767861 our findings indicate that TNFAIP8 overexpression is an independent predictor of platinum resistance in epithelial ovarian cancer
24621012 Our data suggest that TNFAIP8 overexpression may contribute to lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma.
24590269 TNFAIP8 may be used as a prognostic marker for the recurrence of endometrial cancer (EC), and its promotion of the proliferation and metastasis in EC may be due to its mediation of Ki-67 and MMP9.
24464924 SCC-S2 may play roles in affecting both immune cells and tumor cells in the thyroid and may indicate a novel pathway for understanding the pathogenesis of the disease.
24162774 HIV-1 gp120 upregulates the expression of tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) in human B cells
24136748 These results provide evidence that TNFAIP8 plays critical roles in non-small cell lung cancer
23299407 the TNFAIP8-rs11064 Single nucleotide polymorphism may function by affecting the affinity of miR-22 binding to the 3'-untranslated region of TNFAIP8 and regulating TNFAIP8 expression, thus contributing to cervical cancer risk
23280553 TNFAIP8 functions in oncogenesis are likely to involve activation of the integrin, MMP and VEGFR-2 signaling pathways. TNFAIP8 expression revealed correlation of both cytoplasmic and nuclear TNFAIP8 overexpression with high grade prostatic adenocarcinomas
22886548 SCC-S2 is overexpressed in colon cancers.

AA Sequence


Text Mined References (33)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25936980 2015 Expression of tumor necrosis factor ?-induced protein 8 is upregulated in human gastric cancer and regulates cell proliferation, invasion and migration.
25416956 2014 A proteome-scale map of the human interactome network.
25130324 2014 A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
24767861 2014 TNFAIP8 overexpression is associated with platinum resistance in epithelial ovarian cancers with optimal cytoreduction.
24621012 2014 TNFAIP8 overexpression is associated with lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma.
24590269 2014 Correlation of TNFAIP8 overexpression with the proliferation, metastasis, and disease-free survival in endometrial cancer.
24464924 2014 Upregulation of SCC-S2 in immune cells and tumor tissues of papillary thyroid carcinoma.
24136748 2014 Variance of TNFAIP8 expression between tumor tissues and tumor-infiltrating CD4+ and CD8+ T cells in non-small cell lung cancer.
23299407 2013 Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes.