Property Summary

NCBI Gene PubMed Count 26
PubMed Score 20.99
PubTator Score 11.14

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
non-small cell lung cancer 2798 5.49966048583753E-18
posterior fossa group A ependymoma 1511 8.99962639893387E-12
pilocytic astrocytoma 3086 6.6123120730958E-10
psoriasis 6685 3.00306463966206E-7
atypical teratoid / rhabdoid tumor 4369 5.7034878370879E-7
pediatric high grade glioma 2712 1.1950091895025E-6
malignant mesothelioma 3163 1.99211173135605E-6
osteosarcoma 7933 2.22551976059373E-6
lung adenocarcinoma 2714 4.53625149524063E-6
glioblastoma 5572 4.5601500835541E-6
primitive neuroectodermal tumor 3031 3.143862649645E-5
medulloblastoma 1524 3.24266867914485E-5
ovarian cancer 8492 1.18498298830141E-4
medulloblastoma, large-cell 6234 2.69156337470721E-4
lung cancer 4473 4.90797340073605E-4
tuberculosis and treatment for 6 months 686 0.00110122861778578
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00125546792421789
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00151244137170836
primary pancreatic ductal adenocarcinoma 1271 0.00523612031237022
oligodendroglioma 2849 0.00525817438038082
Polycystic Ovary Syndrome 335 0.00707165913877236
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00835493548012716
Breast cancer 3099 0.0215510499526643
Disease Target Count Z-score Confidence
Alzheimer's disease 644 0.0 1.0
Disease Target Count Z-score Confidence
Noonan Syndrome 33 4.094 2.0
LEOPARD Syndrome 20 3.468 1.7



Accession O95297 B2REB9 B2REC0 Q5R332 Q8IX11 Q9BWZ3 Q9NYK4 Q9UL20
Symbols PZR


  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG

Gene RIF (10)

24296779 MPZL1 is a target gene within the 1q24.1-24.2 amplicon that plays a pivotal role in HCC cell migration and tumor metastasis, and a novel MPZL1/Src/cortactin signaling cascade.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19629567 Clinico-electrophysiological features and MRI findings are described in leg musculature from three patients belonging to a CMT2J pedigree due to MPZ Thr124Met mutation.
19536175 Observational study of gene-disease association. (HuGE Navigator)
19064610 Observational study of gene-disease association. (HuGE Navigator)
18568953 Phosphorylation and localization of PZR in cultured endothelial cells is reported.
16702974 Observational study of gene-disease association. (HuGE Navigator)
16702974 the MPZL1/PZR gene may be important in the predisposition to schizophrenia among Han Chinese
12684038 Characterization of PZR1b, an alternative spliced isoform of PZR.
11751924 PZR is a major receptor of ConA and has an important role in cell signaling via c-Src. Considering the various biological activities of ConA, the study of PZR may have major therapeutic implications

AA Sequence


Text Mined References (37)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24296779 2014 Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22881374 2012 Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.