| Tbio | Potassium channel subfamily K member 5 |
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Status Epilepticus | 98 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 5.2e-11 |
| psoriasis | 6694 | 8.7e-08 |
| malignant mesothelioma | 3232 | 1.8e-06 |
| cystic fibrosis | 1696 | 3.0e-05 |
| lung cancer | 4740 | 9.5e-05 |
| osteosarcoma | 7950 | 1.4e-04 |
| ulcerative colitis | 1819 | 3.7e-04 |
| adrenocortical carcinoma | 1428 | 6.6e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.5e-02 |
| active Crohn's disease | 922 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Congenital central hypoventilation syndrome | 18 | 4.24 | 2.1 |
| Birk-Barel syndrome | 8 | 4.239 | 2.1 |
| Interstitial nephritis | 5 | 3.945 | 2.0 |
| Renal tubular acidosis | 24 | 3.005 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.219 | 4.4e-02 |
| adrenocortical carcinoma | -1.221 | 6.6e-04 |
| cystic fibrosis | -2.000 | 3.0e-05 |
| intraductal papillary-mucinous adenoma (... | 1.100 | 1.5e-02 |
| lung adenocarcinoma | 1.500 | 5.2e-11 |
| lung cancer | -1.700 | 9.5e-05 |
| malignant mesothelioma | 2.000 | 1.8e-06 |
| osteosarcoma | -1.982 | 1.4e-04 |
| psoriasis | -1.400 | 8.7e-08 |
| ulcerative colitis | -1.100 | 3.7e-04 |
MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQ 1 - 70 GVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGR 71 - 140 AKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFV 141 - 210 AGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVK 211 - 280 GSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKN 281 - 350 RVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASI 351 - 420 TFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEY 421 - 490 NKANSPKGT 491 - 499 //
