Property Summary

NCBI Gene PubMed Count 25
PubMed Score 26.81
PubTator Score 23.85

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Disease log2 FC p
esophageal adenocarcinoma -3.300 0.020
adrenocortical carcinoma -1.068 0.000
tuberculosis -1.700 0.000
non-small cell lung cancer 2.727 0.000
interstitial cystitis -2.000 0.000
cystic fibrosis 1.200 0.013
nasopharyngeal carcinoma -1.200 0.012
spina bifida -1.544 0.037
ductal carcinoma in situ 1.100 0.034
invasive ductal carcinoma 1.500 0.026
ovarian cancer 1.400 0.000

Synonym

Accession O95274 Q9UJ74
Symbols C4.4A

Gene

Gene RIF (12)

PMID Text
25414274 expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions
24935570 overexpression of C4.4A correlates with metastatic potential of gastric cancer and C4.4A could be a novel independent prognostic marker for predicting outcome.
23918676 Highly expressed C4.4A protein in HER2-positive human breast cancers indicate a good prognosis.
23708783 Tenascin-C expression was significantly associated with C4.4A expression in clinical esophageal squamous carcinoma samples suggesting that there may be a functional role for the C4.4A to induceTenascin-C in vivo.
22431918 the first explanation for the C4.4A contribution to wound healing and metastasis.
22404718 findings suggest that a tight association between C4.4A and tumor budding may, in part, be due to C4.4A promoting epithelial-mesenchymal transition at the invasive front of colorectal cancer
20825414 data indicate that expression of the C4.4A protein at the invasive front acts as a novel prognostic marker in colorectal cancer, possibly through invasion-related mechanisms
18979631 cleavage of C4.4A by ADAM10 and ADAM17 contributes to tumor progression
17912244 we consider C4.4A as a candidate diagnostic marker in colorectal cancer, which possibly can be detected in body fluids
17849475 Overexpression of C4.4A is associated with invasion and metastasis of esophageal squamous cell carcinoma
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AA Sequence

MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVET      1 - 70
IHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVEC     71 - 140
YSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFT    141 - 210
LSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTP    211 - 280
RQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL        281 - 346
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Text Mined References (25)

PMID Year Title
25414274 2015 Expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions.
25293881 2015 The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
24935570 2014 Expression of C4.4A is a potential independent prognostic factor for patients with gastric cancer.
23918676 2015 C4.4A highly expressed in HER2-positive human breast cancers may indicate a good prognosis.
23708783 2013 Concurrent expression of C4.4A and Tenascin-C in tumor cells relates to poor prognosis of esophageal squamous cell carcinoma.
22431918 2012 Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the ?(6)?(4) integrin and MT1-MMP.
22404718 2012 C4.4A is associated with tumor budding and epithelial-mesenchymal transition of colorectal cancer.
20825414 2010 Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancer.
18979631 2008 Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.
17912244 2007 C4.4A as a candidate marker in the diagnosis of colorectal cancer.
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