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  4. Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
  5. 5-hydroxytryptamine receptor subfamily
  6. 5-HT3 receptor sub-subfamily
  7. 5-hydroxytryptamine receptor 3B

Tchem 5-hydroxytryptamine receptor 3B

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

 Comments

Property Summary

Ligand Count 6
NCBI Gene PubMed Count 71
PubMed Score 42.02
PubTator Score 63.25

Knowledge Summary

Patent (3,068)

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Muscular Diseases 27 0.0 0.0
Pain 103 0.0 0.0
Disease Target Count P-value
psoriasis 6694 2.4e-48
ovarian cancer 8520 8.7e-09

Expression

  Differential Expression (2)

Disease log2 FC p
ovarian cancer 1.300 8.7e-09
psoriasis 4.500 2.4e-48

Synonym

Accession O95264 B0YJ23 Q0VJC3 5-HT3-B
Symbols 5-HT3B

Gene

HTR3B

PANTHER Protein Class (4)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (16)

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 GO Function (1)

 GO Component (5)

 GO Process (1)

 Compartment GO Term (19)

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 IMPC Phenotype (1)

 MGI Phenotype (3)

 GWAS Trait (3)

 HCA RNA Cell Line (56)

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Pathway (5)

Drug (6)

Structure of tropisetron

tropisetron
pKi 8.80

Structure of ondansetron

ondansetron
pKi 8.30

Structure of palonosetron

palonosetron
pKd 9.74

Structure of granisetron

granisetron
pKi 8.80

Structure of cisapride

cisapride
pKi 6.82

Structure of metoclopramide

metoclopramide
pKd 7.30

Gene RIF (72)

AA Sequence 

MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILD      1 - 70
VDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSS     71 - 140
GTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELL    141 - 210
SVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVG    211 - 280
YTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADR    281 - 350
PRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY    351 - 420
LFMLGIYTITLCSLWALWGGV                                                     421 - 441
//

Text Mined References (75)

PMID Year Title