Property Summary

NCBI Gene PubMed Count 20
PubMed Score 27.99
PubTator Score 24.50

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
atypical teratoid / rhabdoid tumor 4369 4.23166303984662E-7
osteosarcoma 7933 4.29823971845748E-6
glioblastoma 5572 9.67206670954669E-6
medulloblastoma, large-cell 6234 4.85524853208345E-5
adult high grade glioma 2148 3.58521153864359E-4
medulloblastoma 1524 0.00102604623434757
psoriasis 6685 0.00120243610999749
ovarian cancer 8492 0.00152354096618213
astrocytic glioma 2241 0.0169388624488795
subependymal giant cell astrocytoma 2287 0.0402707461474118
Disease Target Count Z-score Confidence
Congenital nystagmus 26 3.169 1.6


  Differential Expression (10)

Disease log2 FC p
astrocytic glioma -1.200 0.017
psoriasis -1.300 0.001
osteosarcoma -1.774 0.000
atypical teratoid / rhabdoid tumor -1.300 0.000
glioblastoma -1.400 0.000
medulloblastoma -1.100 0.001
medulloblastoma, large-cell -1.200 0.000
adult high grade glioma -1.200 0.000
subependymal giant cell astrocytoma -1.310 0.040
ovarian cancer 1.300 0.002


Accession O95258 D3DTG2 Q0VDH7 Q9HC60 Q9HC61 BMCP-1
Symbols UCP5


  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Zebrafish OMA EggNOG Inparanoid
Fruitfly OMA Inparanoid

Gene RIF (10)

23266757 Increased expression of cerebral UCP5 and UCP4 is observed in a model of high altitude hypoxia and mitochondrial oxidative phosphorylation deficiency.
23266187 Compares and contrasts all the known human SLC25A* genes and includes functional information.
22524567 Neuronal UCP5 exhibits transmembrane chloride transport activity.
22087257 observed significant associations between genetic variants in the SIRT6 and UCP5 genes and atherosclerotic plaque
19910678 The enhanced level of UCP5 is associated to mitochondrial dysfunction in colonic cells.
18018477 The brain may respond to neuroprotection through the increased expression of UCP5 under ischemic conditions.
17066476 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17066476 These findings suggest that UCP2 and UCP4 have a modest but important involvement in the genetic etiology of schizophrenia.
16941493 UCP5 might be physiologically important in the pathology of oxidative stress-induced neurodegeneration
12051969 expressed in skeletal muscle as three different isoforms; expression level of UCP5SI positively correlated with resting metabolic rate and lipid oxidation rate during a euglycemic clamp with infusion of insulin at a physiologic concentration

AA Sequence


Text Mined References (20)

PMID Year Title
23266757 2013 Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude.
23266187 The mitochondrial transporter family SLC25: identification, properties and physiopathology.
23116158 2012 Brain region-specific altered expression and association of mitochondria-related genes in autism.
22950050 2012 Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction.
22524567 2012 Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.
22087257 2011 Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque.
19910678 2009 Hydrogen peroxide regulates the mitochondrial content of uncoupling protein 5 in colon cancer cells.
18018477 2007 Amplified expression of uncoupling proteins in human brain ischemic lesions.
17066476 2007 Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.
16941493 2006 Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity.